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- W2038608936 abstract "INTRODUCTION AND OBJECTIVES: To compare the predictive ability of standard Gleason Score (GS) to a modified one, summing up primary Gleason and the worst score found at the pathologic examination following radical prostatectomy. METHODS: We selected 3490 patients eligible for the study from our database of 3538 radical prostatectomysed cases, collected in the EUREKA-1 multicentric retrospective study on prostate cancer, part of the CHIC European project. We compared the predictive power of standard GS, made up of primary plus second most frequent score at the final pathologic exam after radical prostatectomy, to a simpler one, summing up primary Gleason and the worst score found in the sample (if primary and worst score are the same you have simply to double the score value). The event evaluated was biochemical relapse. Data were analysed with Cox proportional hazard regression model for survival analysis and related Concordance Index (CI). The subgroup of 2707 patients with a follow-up (FU) longer than 30 months was further studied through ROC Area Under the Curve (AUC) analysis. RESULTS: Primary plus worst GS performs slightly better than primary plus secondary GS (CI 1⁄4 0.6587 versus CI 1⁄4 0.6475). In addition, with modified GS it’s possible to split patients into four instead of three risk categories with statistical significance (GS 6, 7, 8 and 9-10 versus 6, 7 and 8-9-10 all together because of a P respectively < 0.001 versus P 1⁄4 0.45 comparing GS 8 and GS 9-10 groups) (Figures 1 and 2). This finding is confirmed by the sub-analysis of patients with a FU longer than 30 months showing a higher ROC AUC of 0.6636 for modified GS versus 0.6523 for the standard one (P 0.0114). CONCLUSIONS: A GS summing up the most frequent score and the worst one performs slightly better than the traditional GS in a huge retrospective cohort of patients. Besides, this modified GS has the advantage of being simpler and quicker during the pathologist’s routine (e.g. no need to report a tertiary higher grade GS), increasing the reliability of pathology reports. SourceofFunding:EuropeanUnionprojectCHIC,Computational Horizons In Cancer, grant agreement number 600841." @default.
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- W2038608936 date "2015-04-01" @default.
- W2038608936 modified "2023-09-22" @default.
- W2038608936 title "MP53-09 A SIMPLER MODIFIED GLEASON SCORE PERFORMS SLIGHTLY BETTER THAN THE STANDARD ONE" @default.
- W2038608936 doi "https://doi.org/10.1016/j.juro.2015.02.1703" @default.
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