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- W2038611382 abstract "Abstract A simple, rapid, and precise method for the determination of 2-dimethylamino-3′,4′-dihydroxyacetophenone hydrochloride in whole blood, plasma, tissue homogenates, or urine has been described. The method is based upon stabilizing this compound in borate buffer prior to column chromatography on anion- and cation-exchange resins followed by ultraviolet absorption spectrophotometry. Utilizing this method, it was observed that nearly 50 % of the administered compound is excreted unchanged in the urine of patients with cancer, and that it is slowly, and poorly metabolized by rat liver in vitro ." @default.
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- W2038611382 date "1968-01-01" @default.
- W2038611382 modified "2023-09-27" @default.
- W2038611382 title "Use of ion-exchange chromatography in the spectrophotometric assay for the antineoplastic agent, 2-dimethylamino-3′,4′-dihydroxyacetophenone hydrochloride, in biological fluids" @default.
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- W2038611382 doi "https://doi.org/10.1016/s0021-9673(01)92930-9" @default.
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