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• W2038613897 endingPage "1603" @default.
• W2038613897 startingPage "1591" @default.
• W2038613897 abstract "ABSTRACT The σ S (or RpoS) subunit of RNA polymerase is the master regulator of the general stress response in Escherichia coli . While nearly absent in rapidly growing cells, σ S is strongly induced during entry into stationary phase and/or many other stress conditions and is essential for the expression of multiple stress resistances. Genome-wide expression profiling data presented here indicate that up to 10% of the E. coli genes are under direct or indirect control of σ S and that σ S should be considered a second vegetative sigma factor with a major impact not only on stress tolerance but on the entire cell physiology under nonoptimal growth conditions. This large data set allowed us to unequivocally identify a σ S consensus promoter in silico. Moreover, our results suggest that σ S -dependent genes represent a regulatory network with complex internal control (as exemplified by the acid resistance genes). This network also exhibits extensive regulatory overlaps with other global regulons (e.g., the cyclic AMP receptor protein regulon). In addition, the global regulatory protein Lrp was found to affect σ S and/or σ 70 selectivity of many promoters. These observations indicate that certain modules of the σ S -dependent general stress response can be temporarily recruited by stress-specific regulons, which are controlled by other stress-responsive regulators that act together with σ 70 RNA polymerase. Thus, not only the expression of genes within a regulatory network but also the architecture of the network itself can be subject to regulation." @default.
• W2038613897 created "2016-06-24" @default.
• W2038613897 creator A5010922092 @default.
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• W2038613897 creator A5086587711 @default.
• W2038613897 creator A5091393671 @default.
• W2038613897 date "2005-03-01" @default.
• W2038613897 modified "2023-10-05" @default.
• W2038613897 title "Genome-Wide Analysis of the General Stress Response Network in <i>Escherichia coli</i> : σ ^S -Dependent Genes, Promoters, and Sigma Factor Selectivity" @default.
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• W2038613897 doi "https://doi.org/10.1128/jb.187.5.1591-1603.2005" @default.
• W2038613897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1063999" @default.
• W2038613897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15716429" @default.
• W2038613897 hasPublicationYear "2005" @default.
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