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• W2038635551 endingPage "417" @default.
• W2038635551 startingPage "408" @default.
• W2038635551 abstract "Aims: Peptide YY (PYY) is an endogenous anorectic gut-secreted peptide that has been shown to suppress appetite in animals and humans, when given by injection. This study tested if needle-free pulmonary delivery of PYY enables food intake suppression and reduced body weight gain in rats. The PYY pharmacokinetics and effects on brain neuropeptide levels were also examined. Methods: Rats received single or once-daily 7-day pulmonary administration of saline or PYYs. Food intake and body weight gain were monitored to study the effects of different doses (0.08–0.90 mg/kg) of PYY3-36, PYY1-36 and PYY13-36. Plasma PYY pharmacokinetics were determined via enzyme-linked immunosorbent assay. Changes in orexigenic neuropeptide Y (NPY) and c-Fos protein levels in the hypothalamus arcuate nucleus (ARC) were measured by immunofluorescence microscopy. Results: PYY3-36 caused dose-dependent and 4- to 6-h food intake suppression following pulmonary delivery. At 0.80 mg/kg, the effect was significant with 35.1 ± 5.7 and 19.7 ± 4.2% suppression at 4 and 6 h, respectively. Repeated administration for 7 days reduced cumulative body weight gain by 39.4 ± 11.0%. PYY1-36, but not PYY13-36, was equipotent to PYY3-36 in food intake suppression. The plasma PYY concentration reached its peak at 10 min following pulmonary delivery with 12–14% of bioavailability. Increased c-Fos and reduced NPY expressions were observed in the hypothalamus ARC, consistent with the magnitude of food intake suppression by each of the PYYs. Conclusions: Pulmonary delivery of PYY enabled significant 4- to 6-h food intake suppression via 12–14% of lung absorption and hypothalamic ARC interaction, leading to reduced body weight gain in rats." @default.
• W2038635551 created "2016-06-24" @default.
• W2038635551 creator A5057981139 @default.
• W2038635551 creator A5065386696 @default.
• W2038635551 creator A5078643615 @default.
• W2038635551 date "2011-03-24" @default.
• W2038635551 modified "2023-09-27" @default.
• W2038635551 title "Pulmonary delivery of peptide YY for food intake suppression and reduced body weight gain in rats" @default.
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• W2038635551 doi "https://doi.org/10.1111/j.1463-1326.2011.01363.x" @default.
• W2038635551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21226821" @default.
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