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• W2038635884 endingPage "249" @default.
• W2038635884 startingPage "249" @default.
• W2038635884 abstract "Rheumatoid arthritis (RA) is recognized to be an autoimmune disease that causes preclinical systemic abnormalities and eventually leads to synovial inflammation and destruction of the joint architecture. Recently identified genetic risk factors and novel insights from animal models of spontaneous arthritis have lent support to the concept that thymic selection of an autoreactive T-cell repertoire is an important risk factor for this disease. With advancing age, defects in the homeostatic control of the T-cell pool and in the setting of signaling thresholds lead to the accumulation of pro-inflammatory T-effector cell populations and loss of tolerance to neo-antigens, such as citrullinated peptides. As the breakdown of tolerance to modified self-antigens can precede synovitis by decades, repair of homeostatic defects may open a unique window of opportunity for preventive interventions in RA. The end result of RA, destruction of cartilage and bone, appears to be driven by cytokine- and cell contact-induced activation of synoviocytes and monocytic cells, some of which differentiate into tissue-destructive osteoclasts. Targeting mediators involved in this process has greatly improved the management of this chronic inflammatory syndrome." @default.
• W2038635884 created "2016-06-24" @default.
• W2038635884 creator A5006681271 @default.
• W2038635884 creator A5056587089 @default.
• W2038635884 date "2009-01-01" @default.
• W2038635884 modified "2023-10-09" @default.
• W2038635884 title "Developments in the scientific understanding of rheumatoid arthritis" @default.
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