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• W2038637564 abstract "Characterization of single-nucleotide polymorphisms is a major focus of current genomics research. We demonstrate the discrimination of DNA mismatches using an elegantly simple microcantilever-based optical deflection assay, without the need for external labeling. Gold-coated silicon AFM cantilevers were functionalized with thiolated 20- or 25-mer probe DNA oligonucleotides and exposed to target oligonucleotides of varying sequence in static and flow conditions. Hybridization of 10-mer complementary target oligonucleotides resulted in net positive deflection, while hybridization with targets containing one or two internal mismatches resulted in net negative deflection. Mismatched targets produced a stable and measurable signal when only a four-base pair stretch was complementary to the probe sequence. This technique is readily adaptable to a high-throughput array format and provides a distinct positive/negative signal for easy interpretation of oligonucleotide hybridization." @default.
• W2038637564 created "2016-06-24" @default.
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• W2038637564 date "2001-03-02" @default.
• W2038637564 modified "2023-10-06" @default.
• W2038637564 title "Cantilever-Based Optical Deflection Assay for Discrimination of DNA Single-Nucleotide Mismatches" @default.
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• W2038637564 doi "https://doi.org/10.1021/ac0012748" @default.
• W2038637564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11321310" @default.
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