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- W2038640606 abstract "Multiple Rabs are associated with secretory granules/vesicles, but how these GTPases are coordinated to promote regulated exocytosis is not well understood. In bladder umbrella cells a subapical pool of discoidal/fusiform-shaped vesicles (DFVs) undergoes Rab11a-dependent regulated exocytosis in response to bladder filling. We show that Rab11a-associated vesicles are enmeshed in an apical cytokeratin meshwork and that Rab11a likely acts upstream of Rab8a to promote exocytosis. Surprisingly, expression of Rabin8, a previously described Rab11a effector and guanine nucleotide exchange factor for Rab8, stimulates stretch-induced exocytosis in a manner that is independent of its catalytic activity. Additional studies demonstrate that the unconventional motor protein myosin5B motor (Myo5B) works in association with the Rab8a-Rab11a module to promote exocytosis, possibly by ensuring transit of DFVs through a subapical, cortical actin cytoskeleton before fusion. Our results indicate that Rab11a, Rab8a, and Myo5B function as part of a network to promote stretch-induced exocytosis, and we predict that similarly organized Rab networks will be common to other regulated secretory pathways." @default.
- W2038640606 created "2016-06-24" @default.
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- W2038640606 date "2013-04-01" @default.
- W2038640606 modified "2023-09-25" @default.
- W2038640606 title "A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells" @default.
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- W2038640606 doi "https://doi.org/10.1091/mbc.e12-08-0568" @default.
- W2038640606 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3608489" @default.
- W2038640606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23389633" @default.
- W2038640606 hasPublicationYear "2013" @default.
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