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- W2038649515 abstract "myo-Inositol 1,4,5-tris(phosphate) was modified at position 6. The analogues synthesized are reported in this publication are 6-deoxy-myo-inositol 1,4,5-tris(phosphate), 6-fluoro-6-deoxy-myo-inositol 1,4,5-tris(phosphate), epi-inositol 1, 4,5-tris(phosphate), and 6-amino-6-deoxy-myo-inositol 1,4, 5-tris(phosphate). These derivatives showed poor affinity for the Ins(1,4,5)P(3) receptors. The inframolecular acid-base behavior and the cooperative effects between the phosphate groups could help explain the loss of affinity of these 6-modified analogues." @default.
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- W2038649515 date "1999-10-23" @default.
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- W2038649515 title "Synthesis, Acid−Base Behavior, and Binding Properties of 6-Modified <i>myo</i>-Inositol 1,4,5-Tris(phosphate)s" @default.
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- W2038649515 doi "https://doi.org/10.1021/jm991084t" @default.
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