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- W2038672345 abstract "Biopsy specimens of involved and uninvolved skin were studied in 8 patients suffering from generalized lichen planus (LP) before and after successful etretinate treatment using murine monoclonal antibodies against several cell surface markers of effector and/or accessory cells of the immune system. In contrast to untreated LP-lesions, in biopsies obtained after etretinate therapy from healed involved skin a markedly disintegrated HLA-DR expression on keratinocytes and intraepidermal Langerhans cells and a nearly total loss of suppressor/cytotoxic T lymphocytes at the dermo-epidermal interface were found. Our data emphasize the key position of the class II antigen expression on various immunocompetent cells, as a marker for a cell-mediated immune reaction, on the other hand, stress the involvement of keratinocytes, Langerhans cells and suppressor/cytotoxic T lymphocytes in the pathogenesis of LP." @default.
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- W2038672345 date "1990-05-01" @default.
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- W2038672345 title "Immunopathological Aspects of Etretinate Therapy in Lichen Planus" @default.
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- W2038672345 doi "https://doi.org/10.1111/j.1346-8138.1990.tb01642.x" @default.
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