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• W2038673967 abstract "No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Nov 2002A Double-Blind Crossover Study Evaluating the Efficacy of Korean Red Ginseng in Patients With Erectile Dysfunction: A Preliminary Report BUMSIK HONG, YOUNG HWAN JI, JUN HYUK HONG, K.I. YEUL NAM, and TAI YOUNG AHN BUMSIK HONGBUMSIK HONG More articles by this author , YOUNG HWAN JIYOUNG HWAN JI More articles by this author , JUN HYUK HONGJUN HYUK HONG More articles by this author , K.I. YEUL NAMK.I. YEUL NAM More articles by this author , and TAI YOUNG AHNTAI YOUNG AHN More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64298-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the efficacy of Korean red ginseng for erectile dysfunction using the International Index of Erectile Function, RigiScan (UroHealth Systems, Laguna Niguel, California), hormonal levels and penile duplex ultrasonography with audiovisual sexual stimulation. Materials and Methods: A total of 45 patients with clinically diagnosed erectile dysfunction were enrolled in a double-blind, placebo controlled, crossover study (8 weeks on treatment, 2 weeks of washout and 8 weeks on treatment) in which the effects of Korean red ginseng and a vehicle placebo were compared using multiple variables. The ginseng dose was 900 mg. 3 times daily. Results: Mean International Index of Erectile Function scores were significantly higher in patients treated with Korean red ginseng than in those who received placebo (baseline 28.0 ± 16.7 and 38.1 ± 16.6 versus 30.9 ± 15.7, p <0.01). Scores on questions 3 (penetration) and 4 (maintenance) were significantly higher in the ginseng than in the placebo group (p <0.01). In response to the global efficacy question 60% of the patients answered that Korean red ginseng improved erection (p <0.01). Among other variables penile tip rigidity on RigiScan showed significant improvement for ginseng versus placebo. Conclusions: Our data show that Korean red ginseng can be as effective alternative for treating male erectile dysfunction. References 1 : Effect of ginseng on relaxation of penile corpus cavernosal smooth muscle in rabbits. J Urol1996; 155: 618A. abstract 1228. Google Scholar 2 : Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol1999; 58: 1685. Google Scholar 3 : Ginsengs: a review of safety and efficacy. Nutr Clin Care2000; 3: 90. Google Scholar 4 : Probable interaction between warfarin and ginseng. Am J Health Syst Pharm1997; 54: 692. Google Scholar 5 : Key issues from the clinical trials of apomorphine SL. World J Urol2001; 19: 25. Google Scholar 6 : Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions. Int J Androl2000; 23: 82. Google Scholar 7 : A review of 12 commonly used medicinal herbs. Arch Fam Med1998; 7: 523. Google Scholar 8 : Panax ginseng pharmacology: a nitric oxide link?. Biochem Pharmacol1997; 54: 1. Google Scholar 9 : Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br J Pharmacol1995; 115: 15. Google Scholar 10 : Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle. Int J Impot Res1998; 10: 37. Google Scholar 11 : Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impot Res1995; 7: 181. Google Scholar 12 : Effects of Panax Ginseng root on conditioned avoidance response in rats. Jpn J Pharmacol1977; 27: 509. Google Scholar 13 : A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol1986; 16: 15. Google Scholar 14 : Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med1985; 3: 221. Google Scholar 15 : Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors. Gen Pharmacol1994; 25: 193. Google Scholar From the Department of Urology, University of Ulsan College of Medicine, Asan Medical Center and Korea Ginseng and Tobacco Research Institute, Seoul, Korea© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byMONTAGUE D, JAROW J, BRODERICK G, DMOCHOWSKI R, HEATON J, LUE T, MILBANK A, NEHRA A and SHARLIP I (2018) CHAPTER 1: THE MANAGEMENT OF ERECTILE DYSFUNCTION: AN AUA UPDATEJournal of Urology, VOL. 174, NO. 1, (230-239), Online publication date: 1-Jul-2005. Volume 168Issue 5November 2002Page: 2070-2073 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.KeywordspenisimpotencePanaxquestionnairesMetricsAuthor Information BUMSIK HONG More articles by this author YOUNG HWAN JI More articles by this author JUN HYUK HONG More articles by this author K.I. YEUL NAM More articles by this author TAI YOUNG AHN More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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