FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038675211> ?p ?o ?g. }

• W2038675211 endingPage "20035" @default.
• W2038675211 startingPage "20030" @default.
• W2038675211 abstract "Proteins evolve at very different rates and, most notably, at rates inversely proportional to the level at which they are produced. The relative frequency of highly expressed proteins in the proteome, and thus their impact on the cell budget, increases steeply with growth rate. The maximal growth rate is a key life-history trait reflecting trade-offs between rapid growth and other fitness components. We show that the maximal growth rate is weakly affected by genetic drift. The negative correlation between protein expression levels and evolutionary rate and the positive correlation between expression levels of highly expressed proteins and growth rates, suggest that investment in growth affects the evolutionary rate of proteins, especially the highly expressed ones. Accordingly, analysis of 61 families of orthologs in 74 proteobacteria shows that differences in evolutionary rates between lowly and highly expressed proteins depend on maximal growth rates. Analyses of complexes with key roles in bacterial growth and strikingly different expression levels, the ribosome and the replisome, confirm these patterns and suggest that the growth-related sequence conservation is associated with protein synthesis. Maximal growth rates also shape protein evolution in the other bacterial clades. Long-branch attractions associated with this effect might explain why clades with persistent history of slow growth are attracted to the root when the tree of prokaryotes is inferred using highly, but not lowly, expressed proteins. These results indicate that reconstruction of deep phylogenies can be strongly affected by maximal growth rates, and highlight the importance of life-history traits and their physiological consequences for protein evolution." @default.
• W2038675211 created "2016-06-24" @default.
• W2038675211 creator A5010183798 @default.
• W2038675211 creator A5022452005 @default.
• W2038675211 creator A5027041249 @default.
• W2038675211 creator A5071739266 @default.
• W2038675211 date "2011-11-30" @default.
• W2038675211 modified "2023-10-16" @default.
• W2038675211 title "Investment in rapid growth shapes the evolutionary rates of essential proteins" @default.
• W2038675211 cites W1966972227 @default.
• W2038675211 cites W1968179480 @default.
• W2038675211 cites W1990507322 @default.
• W2038675211 cites W2001721767 @default.
• W2038675211 cites W2016170819 @default.
• W2038675211 cites W2023805311 @default.
• W2038675211 cites W2034598535 @default.
• W2038675211 cites W2039790548 @default.
• W2038675211 cites W2041852635 @default.
• W2038675211 cites W2053460598 @default.
• W2038675211 cites W2062299407 @default.
• W2038675211 cites W2062354928 @default.
• W2038675211 cites W2078969200 @default.
• W2038675211 cites W2109436337 @default.
• W2038675211 cites W2110335151 @default.
• W2038675211 cites W2112515372 @default.
• W2038675211 cites W2115148114 @default.
• W2038675211 cites W2118001436 @default.
• W2038675211 cites W2127148540 @default.
• W2038675211 cites W2132589078 @default.
• W2038675211 cites W2135697951 @default.
• W2038675211 cites W2136437557 @default.
• W2038675211 cites W2136749660 @default.
• W2038675211 cites W2137164960 @default.
• W2038675211 cites W2138309685 @default.
• W2038675211 cites W2143470360 @default.
• W2038675211 cites W2147126179 @default.
• W2038675211 cites W2150690480 @default.
• W2038675211 cites W2151409320 @default.
• W2038675211 cites W2156536014 @default.
• W2038675211 cites W2157848631 @default.
• W2038675211 cites W2163373465 @default.
• W2038675211 cites W2169079604 @default.
• W2038675211 doi "https://doi.org/10.1073/pnas.1110972108" @default.
• W2038675211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3250144" @default.
• W2038675211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22135464" @default.
• W2038675211 hasPublicationYear "2011" @default.
• W2038675211 type Work @default.
• W2038675211 sameAs 2038675211 @default.
• W2038675211 citedByCount "8" @default.
• W2038675211 countsByYear W20386752112012 @default.
• W2038675211 countsByYear W20386752112013 @default.
• W2038675211 countsByYear W20386752112014 @default.
• W2038675211 countsByYear W20386752112015 @default.
• W2038675211 countsByYear W20386752112016 @default.
• W2038675211 countsByYear W20386752112021 @default.
• W2038675211 crossrefType "journal-article" @default.
• W2038675211 hasAuthorship W2038675211A5010183798 @default.
• W2038675211 hasAuthorship W2038675211A5022452005 @default.
• W2038675211 hasAuthorship W2038675211A5027041249 @default.
• W2038675211 hasAuthorship W2038675211A5071739266 @default.
• W2038675211 hasBestOaLocation W20386752111 @default.
• W2038675211 hasConcept C104317684 @default.
• W2038675211 hasConcept C2524010 @default.
• W2038675211 hasConcept C2778312390 @default.
• W2038675211 hasConcept C33923547 @default.
• W2038675211 hasConcept C44465124 @default.
• W2038675211 hasConcept C54355233 @default.
• W2038675211 hasConcept C78458016 @default.
• W2038675211 hasConcept C86803240 @default.
• W2038675211 hasConcept C90132467 @default.
• W2038675211 hasConceptScore W2038675211C104317684 @default.
• W2038675211 hasConceptScore W2038675211C2524010 @default.
• W2038675211 hasConceptScore W2038675211C2778312390 @default.
• W2038675211 hasConceptScore W2038675211C33923547 @default.
• W2038675211 hasConceptScore W2038675211C44465124 @default.
• W2038675211 hasConceptScore W2038675211C54355233 @default.
• W2038675211 hasConceptScore W2038675211C78458016 @default.
• W2038675211 hasConceptScore W2038675211C86803240 @default.
• W2038675211 hasConceptScore W2038675211C90132467 @default.
• W2038675211 hasIssue "50" @default.
• W2038675211 hasLocation W20386752111 @default.
• W2038675211 hasLocation W20386752112 @default.
• W2038675211 hasLocation W20386752113 @default.
• W2038675211 hasLocation W20386752114 @default.
• W2038675211 hasOpenAccess W2038675211 @default.
• W2038675211 hasPrimaryLocation W20386752111 @default.
• W2038675211 hasRelatedWork W1843948483 @default.
• W2038675211 hasRelatedWork W1970895961 @default.
• W2038675211 hasRelatedWork W2008164867 @default.
• W2038675211 hasRelatedWork W2009494982 @default.
• W2038675211 hasRelatedWork W2055925137 @default.
• W2038675211 hasRelatedWork W2073704098 @default.
• W2038675211 hasRelatedWork W2968219990 @default.
• W2038675211 hasRelatedWork W2990771211 @default.
• W2038675211 hasRelatedWork W4229549692 @default.
• W2038675211 hasRelatedWork W4361859526 @default.
• W2038675211 hasVolume "108" @default.
• W2038675211 isParatext "false" @default.

• next