FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038681780> ?p ?o ?g. }

• W2038681780 endingPage "334" @default.
• W2038681780 startingPage "326" @default.
• W2038681780 abstract "This series of studies examines the pharmacokinetic/pharmacodynamic interactions between buprenorphine, an opioid partial agonist increasingly used in treatment of opioid dependence, and rifampin, a medication used as a first line treatment for tuberculosis; or rifabutin, an alternative antituberculosis medication. Opioid-dependent individuals on stable doses of buprenorphine/naloxone underwent two, 24-h blood sampling studies: (1) for buprenorphine pharmacokinetics and (2) following 15 days of rifampin 600 mg daily or rifabutin 300 mg daily for buprenorphine and rifampin or rifabutin pharmacokinetics. Rifampin administration produced significant reduction in plasma buprenorphine concentrations (70% reduction in mean area under the curve (AUC); p = <0.001) and onset of opiate withdrawal symptoms in 50% of participants (p = 0.02). While rifabutin administration to buprenorphine-maintained subjects resulted in a significant decrease in buprenorphine plasma concentrations (35% decrease in AUC; p < 0.001) no opiate withdrawal was seen. Compared with historical control data, buprenorphine had no significant effect on rifampin pharmacokinetics, but was associated with 22% lower rifabutin mean AUC (p = 0.009), although rifabutin and its active metabolite concentrations remained in the therapeutic range. Rifampin is a more potent inducer of buprenorphine metabolism than rifabutin with pharmacokinetic and pharmacodynamic adverse consequences. Those patients requiring rifampin treatment for tuberculosis and receiving buprenorphine therapy are likely to require an increase in buprenorphine dose to prevent withdrawal symptoms. Rifabutin administration was associated with decreases in buprenorphine plasma concentrations, but no clinically significant adverse events were observed." @default.
• W2038681780 created "2016-06-24" @default.
• W2038681780 creator A5023959197 @default.
• W2038681780 creator A5027086287 @default.
• W2038681780 creator A5031442075 @default.
• W2038681780 creator A5062323483 @default.
• W2038681780 creator A5072635409 @default.
• W2038681780 date "2011-11-01" @default.
• W2038681780 modified "2023-10-18" @default.
• W2038681780 title "Rifampin, but not rifabutin, may produce opiate withdrawal in buprenorphine-maintained patients" @default.
• W2038681780 cites W1748596291 @default.
• W2038681780 cites W1847168837 @default.
• W2038681780 cites W1877120840 @default.
• W2038681780 cites W1967344273 @default.
• W2038681780 cites W1977024854 @default.
• W2038681780 cites W1979600943 @default.
• W2038681780 cites W1992398275 @default.
• W2038681780 cites W1994145243 @default.
• W2038681780 cites W2001592123 @default.
• W2038681780 cites W2004429342 @default.
• W2038681780 cites W2013596423 @default.
• W2038681780 cites W2018914766 @default.
• W2038681780 cites W2019939029 @default.
• W2038681780 cites W2030021013 @default.
• W2038681780 cites W2033991790 @default.
• W2038681780 cites W2037118657 @default.
• W2038681780 cites W2039011163 @default.
• W2038681780 cites W2044951617 @default.
• W2038681780 cites W2057416007 @default.
• W2038681780 cites W2069246292 @default.
• W2038681780 cites W2070866101 @default.
• W2038681780 cites W2076198515 @default.
• W2038681780 cites W2081660660 @default.
• W2038681780 cites W2082052010 @default.
• W2038681780 cites W2086774100 @default.
• W2038681780 cites W2089663335 @default.
• W2038681780 cites W2094738707 @default.
• W2038681780 cites W2095787895 @default.
• W2038681780 cites W2104000264 @default.
• W2038681780 cites W2104823961 @default.
• W2038681780 cites W2105540175 @default.
• W2038681780 cites W2110037828 @default.
• W2038681780 cites W2122374426 @default.
• W2038681780 cites W2130069006 @default.
• W2038681780 cites W2139579626 @default.
• W2038681780 cites W219901841 @default.
• W2038681780 doi "https://doi.org/10.1016/j.drugalcdep.2011.04.013" @default.
• W2038681780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3272858" @default.
• W2038681780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21596492" @default.
• W2038681780 hasPublicationYear "2011" @default.
• W2038681780 type Work @default.
• W2038681780 sameAs 2038681780 @default.
• W2038681780 citedByCount "36" @default.
• W2038681780 countsByYear W20386817802012 @default.
• W2038681780 countsByYear W20386817802013 @default.
• W2038681780 countsByYear W20386817802014 @default.
• W2038681780 countsByYear W20386817802015 @default.
• W2038681780 countsByYear W20386817802016 @default.
• W2038681780 countsByYear W20386817802017 @default.
• W2038681780 countsByYear W20386817802018 @default.
• W2038681780 countsByYear W20386817802019 @default.
• W2038681780 countsByYear W20386817802020 @default.
• W2038681780 countsByYear W20386817802021 @default.
• W2038681780 countsByYear W20386817802022 @default.
• W2038681780 countsByYear W20386817802023 @default.
• W2038681780 crossrefType "journal-article" @default.
• W2038681780 hasAuthorship W2038681780A5023959197 @default.
• W2038681780 hasAuthorship W2038681780A5027086287 @default.
• W2038681780 hasAuthorship W2038681780A5031442075 @default.
• W2038681780 hasAuthorship W2038681780A5062323483 @default.
• W2038681780 hasAuthorship W2038681780A5072635409 @default.
• W2038681780 hasBestOaLocation W20386817802 @default.
• W2038681780 hasConcept C111113717 @default.
• W2038681780 hasConcept C112705442 @default.
• W2038681780 hasConcept C126322002 @default.
• W2038681780 hasConcept C170493617 @default.
• W2038681780 hasConcept C2776409635 @default.
• W2038681780 hasConcept C2776962512 @default.
• W2038681780 hasConcept C2777972943 @default.
• W2038681780 hasConcept C2778140631 @default.
• W2038681780 hasConcept C2778949969 @default.
• W2038681780 hasConcept C2780867798 @default.
• W2038681780 hasConcept C2781063702 @default.
• W2038681780 hasConcept C42219234 @default.
• W2038681780 hasConcept C71924100 @default.
• W2038681780 hasConcept C97320921 @default.
• W2038681780 hasConcept C98274493 @default.
• W2038681780 hasConceptScore W2038681780C111113717 @default.
• W2038681780 hasConceptScore W2038681780C112705442 @default.
• W2038681780 hasConceptScore W2038681780C126322002 @default.
• W2038681780 hasConceptScore W2038681780C170493617 @default.
• W2038681780 hasConceptScore W2038681780C2776409635 @default.
• W2038681780 hasConceptScore W2038681780C2776962512 @default.
• W2038681780 hasConceptScore W2038681780C2777972943 @default.
• W2038681780 hasConceptScore W2038681780C2778140631 @default.
• W2038681780 hasConceptScore W2038681780C2778949969 @default.
• W2038681780 hasConceptScore W2038681780C2780867798 @default.
• W2038681780 hasConceptScore W2038681780C2781063702 @default.

• next