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- W2038686306 abstract "Carotid body glomus cells sense hypoxia through the inhibition of plasmalemmal K+ channels, which leads to Ca2+ influx and transmitter release. Although the mechanism of O2 sensing remains enigmatic, it does not seem to depend on cellular redox status or inhibition of mitochondrial electron transport. Hypoxia inducible factors appear to be necessary for the expression of the O2 sensor and carotid body remodeling in chronic hypoxia, but are not directly involved in acute O2 sensing. Glomus cells are also rapidly activated by reductions of glucose concentration due to inhibition of K+ channels. These cells function as combined O2 and glucose sensors that help to prevent neuronal damage by acute hypoxia and/or hypoglycemia." @default.
- W2038686306 created "2016-06-24" @default.
- W2038686306 creator A5089834834 @default.
- W2038686306 date "2003-08-01" @default.
- W2038686306 modified "2023-10-15" @default.
- W2038686306 title "Oxygen and glucose sensing by carotid body glomus cells" @default.
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- W2038686306 doi "https://doi.org/10.1016/s0959-4388(03)00093-x" @default.
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