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• W2038689269 abstract "The quantification of excitatory and inhibitory neurotransmission and the associated energy metabolism is crucial for a proper understanding of brain function. Although the detection of glutamatergic neurotransmission in vivo by (13)C NMR spectroscopy is now relatively routine, the detection of GABAergic neurotransmission in vivo has remained elusive because of the low GABA concentration and spectral overlap. Using (1)H-[(13)C] NMR spectroscopy at high magnetic field in combination with robust spectral modeling and the use of different substrates, [U-(13)C(6)]-glucose and [2-(13)C]-acetate, it is shown that GABAergic, as well as glutamatergic neurotransmitter fluxes can be detected non-invasively in rat brain in vivo." @default.
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• W2038689269 date "2010-01-01" @default.
• W2038689269 modified "2023-10-16" @default.
• W2038689269 title "<i>In vivo</i>neurochemical profiling of rat brain by¹H-[¹³C] NMR spectroscopy: cerebral energetics and glutamatergic/GABAergic neurotransmission" @default.
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• W2038689269 doi "https://doi.org/10.1111/j.1471-4159.2009.06428.x" @default.
• W2038689269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2843425" @default.
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