FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038705037> ?p ?o ?g. }

• W2038705037 endingPage "292" @default.
• W2038705037 startingPage "287" @default.
• W2038705037 abstract "Zuccagnia punctata Cav. (Fabaceae) is a monotypic species distributed in western Argentina and is traditionally used for the treatment of bacterial and fungal infections. The aim of this study was to demonstrated the antibacterial activity of the Zuccagnia punctata standardized extract and the structurally related non-methoxylated flavonoids with similar pattern of substitution and differences in ring C present in this plant species: 7-hydroxyflavanone (HF), 2′,4′-dihydroxychalcone (DHC) and 3,7-dihydroxyflavone (DHF), against Streptococcus pneumoniae clinical isolates using in vitro and in vivo models. MIC values of natural products were determined by agar macrodilution method. In vivo activities were investigated in a Streptococcus pneumoniae infection model in mice. Lung and blood samples were obtained for bacterial cell counts. The serum was used by biochemical analysis (alanine transaminase, aspartate transaminase, urea and creatinine) in order to evaluate the toxicity of natural products. All samples showed antimicrobial activity in vitro with MIC values between 50 and 500 μg/ml. Zuccagnia punctata extract (1 mg/mice) and HF (1 mg/mice) significantly reduced the number of viable Streptococcus pneumoniae in lung (p < 0.01) while lower quantities has not effect. Therefore, the present study has shown that intake once or twice a day of 1 mg of Zuccagnia punctata extract or HF for seven days did not result in toxicity. Our results showed that Zuccagnia punctata extract as well as one of its isolated flavonoids, 7-hydroxyflavanone, could be useful for the development of a novel respiratory infections treatment." @default.
• W2038705037 created "2016-06-24" @default.
• W2038705037 creator A5007383548 @default.
• W2038705037 creator A5019908956 @default.
• W2038705037 creator A5078554476 @default.
• W2038705037 creator A5085416915 @default.
• W2038705037 creator A5086075387 @default.
• W2038705037 creator A5088920458 @default.
• W2038705037 date "2012-03-01" @default.
• W2038705037 modified "2023-10-09" @default.
• W2038705037 title "Potentiality of standardized extract and isolated flavonoids from Zuccagnia punctata for the treatment of respiratory infections by Streptococcus pneumoniae: In vitro and in vivo studies" @default.
• W2038705037 cites W1528049380 @default.
• W2038705037 cites W1559903407 @default.
• W2038705037 cites W1964655326 @default.
• W2038705037 cites W1993571970 @default.
• W2038705037 cites W1993635651 @default.
• W2038705037 cites W1994348425 @default.
• W2038705037 cites W2005854408 @default.
• W2038705037 cites W2011880631 @default.
• W2038705037 cites W2013794249 @default.
• W2038705037 cites W2022114951 @default.
• W2038705037 cites W2027843873 @default.
• W2038705037 cites W2037506452 @default.
• W2038705037 cites W2042628473 @default.
• W2038705037 cites W2054314467 @default.
• W2038705037 cites W2058377010 @default.
• W2038705037 cites W2072371701 @default.
• W2038705037 cites W2080860563 @default.
• W2038705037 cites W2082545176 @default.
• W2038705037 cites W2094768851 @default.
• W2038705037 cites W2104669061 @default.
• W2038705037 cites W2118425655 @default.
• W2038705037 cites W2122234707 @default.
• W2038705037 cites W2153703055 @default.
• W2038705037 cites W2168313361 @default.
• W2038705037 cites W2168613507 @default.
• W2038705037 cites W2423750299 @default.
• W2038705037 cites W2938044065 @default.
• W2038705037 doi "https://doi.org/10.1016/j.jep.2012.01.019" @default.
• W2038705037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22285202" @default.
• W2038705037 hasPublicationYear "2012" @default.
• W2038705037 type Work @default.
• W2038705037 sameAs 2038705037 @default.
• W2038705037 citedByCount "30" @default.
• W2038705037 countsByYear W20387050372012 @default.
• W2038705037 countsByYear W20387050372013 @default.
• W2038705037 countsByYear W20387050372014 @default.
• W2038705037 countsByYear W20387050372015 @default.
• W2038705037 countsByYear W20387050372017 @default.
• W2038705037 countsByYear W20387050372018 @default.
• W2038705037 countsByYear W20387050372019 @default.
• W2038705037 countsByYear W20387050372020 @default.
• W2038705037 countsByYear W20387050372021 @default.
• W2038705037 countsByYear W20387050372022 @default.
• W2038705037 countsByYear W20387050372023 @default.
• W2038705037 crossrefType "journal-article" @default.
• W2038705037 hasAuthorship W2038705037A5007383548 @default.
• W2038705037 hasAuthorship W2038705037A5019908956 @default.
• W2038705037 hasAuthorship W2038705037A5078554476 @default.
• W2038705037 hasAuthorship W2038705037A5085416915 @default.
• W2038705037 hasAuthorship W2038705037A5086075387 @default.
• W2038705037 hasAuthorship W2038705037A5088920458 @default.
• W2038705037 hasConcept C116263406 @default.
• W2038705037 hasConcept C126322002 @default.
• W2038705037 hasConcept C150903083 @default.
• W2038705037 hasConcept C160160445 @default.
• W2038705037 hasConcept C181199279 @default.
• W2038705037 hasConcept C202751555 @default.
• W2038705037 hasConcept C207001950 @default.
• W2038705037 hasConcept C2779679107 @default.
• W2038705037 hasConcept C2781253189 @default.
• W2038705037 hasConcept C29730261 @default.
• W2038705037 hasConcept C4937899 @default.
• W2038705037 hasConcept C501593827 @default.
• W2038705037 hasConcept C55493867 @default.
• W2038705037 hasConcept C556039675 @default.
• W2038705037 hasConcept C71924100 @default.
• W2038705037 hasConcept C86803240 @default.
• W2038705037 hasConcept C89423630 @default.
• W2038705037 hasConcept C98274493 @default.
• W2038705037 hasConceptScore W2038705037C116263406 @default.
• W2038705037 hasConceptScore W2038705037C126322002 @default.
• W2038705037 hasConceptScore W2038705037C150903083 @default.
• W2038705037 hasConceptScore W2038705037C160160445 @default.
• W2038705037 hasConceptScore W2038705037C181199279 @default.
• W2038705037 hasConceptScore W2038705037C202751555 @default.
• W2038705037 hasConceptScore W2038705037C207001950 @default.
• W2038705037 hasConceptScore W2038705037C2779679107 @default.
• W2038705037 hasConceptScore W2038705037C2781253189 @default.
• W2038705037 hasConceptScore W2038705037C29730261 @default.
• W2038705037 hasConceptScore W2038705037C4937899 @default.
• W2038705037 hasConceptScore W2038705037C501593827 @default.
• W2038705037 hasConceptScore W2038705037C55493867 @default.
• W2038705037 hasConceptScore W2038705037C556039675 @default.
• W2038705037 hasConceptScore W2038705037C71924100 @default.
• W2038705037 hasConceptScore W2038705037C86803240 @default.
• W2038705037 hasConceptScore W2038705037C89423630 @default.
• W2038705037 hasConceptScore W2038705037C98274493 @default.

• next