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- W2038713019 startingPage "235" @default.
- W2038713019 abstract "Quantitative cytochrome oxidase (CO) histochemistry provides an intracellular measure of oxidative energy meta bolic capacity that can be used as a tool to evaluate brain functional changes. CO enzyme activity also has been shown to be catalytically abnormal in patients with Alzhei mer's disease (AD). The application of CO histochemistry to postmortem AD and control human brains, as well as in comparative studies of murine models, is presented here, from the cellular to laminar to regional and multiregional levels of analysis. In AD cases and controls, we compared CO in I 1 brain regions-of-interest (ROIs), including lami nar analyses in seven neocortical regions. In a transgenic mouse model of AD and controls, we compared CO in 56 ROIs, providing information about both regional and net work activity. Results highlight cellular and laminar vulner abilities in AD and illustrate homologies between AD cases and a murine model of AD, with age-related reductions in CO activity within circuits implicated in spatial and dis criminative learning. Quantitative CO histochemistr y is a useful tool for the ex vivo assessment of functional changes within brain regions and neural networks, and its applica tion has provided support for the hypothesis that mitochon drial dysfunction is involved in the pathophysiology of AD. (The J Histotechnol 30:235, 2007)" @default.
- W2038713019 created "2016-06-24" @default.
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- W2038713019 creator A5051090841 @default.
- W2038713019 creator A5051296393 @default.
- W2038713019 date "2007-12-01" @default.
- W2038713019 modified "2023-10-16" @default.
- W2038713019 title "Quantitative Cytochrome Oxidase Histochemistry: Applications in Human Alzheimer's Disease and Animal Models" @default.
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- W2038713019 doi "https://doi.org/10.1179/his.2007.30.4.235" @default.
- W2038713019 hasPublicationYear "2007" @default.
- W2038713019 type Work @default.