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- W2038727783 abstract "We investigated the effect of omeprazole (1×10−5–3×10−4 M), an inhibitor of H+,K+-ATPase, on rat aortic rings pre-contracted with phenylephrine (10−6 M). Omeprazole relaxed the tissue in a concentration-dependent manner. Either removal of the endothelium or incubation with nitric oxide (NO) synthase inhibitor NG-nitro-l-arginine methyl ester (l-NAME, 3×10−5 M) significantly attenuated the relaxations. Pre-treatment with l-arginine (10−3 M), but not with d-arginine, reversed the inhibitory action of l-NAME. Indomethacin (10−6 M) and tetraethylammonium (TEA, 10−2 M) did not affect the relaxant responses to omeprazole indicating the lack of involvement of cyclooxygenase products and K+ channels, respectively. These results suggest a role of NO in the mechanism of action of omeprazole." @default.
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- W2038727783 date "2002-10-01" @default.
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- W2038727783 title "OMEPRAZOLE-INDUCED RELAXATION IN RAT AORTA IS PARTLY DEPENDENT ON ENDOTHELIUM" @default.
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- W2038727783 doi "https://doi.org/10.1016/s104366180200124x" @default.
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