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- W2038730656 abstract "We have measured cholesterol biosynthesis invitro by normal and leukenic (L2C) guinea pig lymphocytes. As shown before (Philippot, J. R., Cooper, A. C. and Wallach, D. F.E. [1975] Biochim. Biophys. Acta 406: 161–166) L2C cells produce cholesterol at 25–60 times the rate found with normal cells. 25-hydroxycholecalciferol and 1, 25-dihydorxycholecalciferol, both biologically active derivatives of vitamin D3, at submicromolar concentrations inhibit cholesterol biosynthesis by both normal and neoplastic lymphocytes. Unoxygenated vitamin D3 was not inhibitory. The rate of inhibitioin due to 25-hydroxychelecalciferol is considerably greater than that of the oxygenated cholesterol analogs." @default.
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- W2038730656 date "1976-10-01" @default.
- W2038730656 modified "2023-09-23" @default.
- W2038730656 title "25-Hydroxycholecalciferol and 1, 25-dihydroxycholecalciferol are potent inhibitors of cholesterol biosynthesis by normal and leukemic (L2C) guinea pig lymphocytes" @default.
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- W2038730656 doi "https://doi.org/10.1016/s0006-291x(76)80236-7" @default.
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