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- W2038744564 abstract "Custard apple (Annona squamosa L.) is an edible tropical fruit, and its seeds had been used in south China as a folk medicine to treat malignant sore (cancer) and as an insecticide. Phytochemical investigation of the ethanol fraction of custard apple seeds led to the isolation of six new annonaceous acetogenins: annosquacins A-D (1-4), annosquatin A (5) and annosquatin B (6). Their structures were elucidated by spectroscopic analysis. Compounds 1-4 are adjacent bistetrahydrofuran annonaceous acetogenins. Compounds 5 and 6 are non-adjacent bistetrahydrofuran annonaceous acetogenins and the first examples in which the tetrahydrofuran ring system is located between C-9 and C-20. The absolute configurations of 1-6 were defined by the application of the Mosher method. Compounds 1-6 exhibited potent cytotoxic activity in vitro against five human tumour cell lines. Compounds 5 and 6 showed a high selectivity toward the MCF-7 and A-549 cell line respectively." @default.
- W2038744564 created "2016-06-24" @default.
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- W2038744564 date "2012-12-01" @default.
- W2038744564 modified "2023-10-17" @default.
- W2038744564 title "Six cytotoxic annonaceous acetogenins from Annona squamosa seeds" @default.
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- W2038744564 doi "https://doi.org/10.1016/j.foodchem.2012.05.041" @default.
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