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• W2038745440 endingPage "20130503" @default.
• W2038745440 startingPage "20130503" @default.
• W2038745440 abstract "We have previously demonstrated the release of membranous structures by cells into their extracellular environment, which are termed exosomes, microvesicles or extracellular vesicles depending on specific characteristics, including size, composition and biogenesis pathway. With activation, injury, stress, transformation or infection, cells express proteins and RNAs associated with the cellular responses to these events. The exosomes released by these cells can exhibit an array of proteins, lipids and nucleic acids linked to these physiologic events. This review focuses on exosomes associated with traumatic brain injury, which may be both diagnostic and a causative factor in the progression of the injury. Based on current data, exosomes play essential roles as conveyers of intercellular communication and mediators of many of the pathological conditions associated with development, progression and therapeutic failures and cellular stress in a variety of pathologic conditions. These extracellular vesicles express components responsible for angiogenesis promotion, stromal remodelling, signal pathway activation through growth factor/receptor transfer, chemoresistance, immunologic activation and genetic exchange. These circulating exosomes not only represent a central mediator of the pro-inflammatory microenvironment linked with secondary brain injury, but their presence in the peripheral circulation may serve as a surrogate for biopsies, enabling real-time diagnosis and monitoring of neurodegenerative progression." @default.
• W2038745440 created "2016-06-24" @default.
• W2038745440 creator A5056184501 @default.
• W2038745440 creator A5090524010 @default.
• W2038745440 date "2014-09-26" @default.
• W2038745440 modified "2023-10-01" @default.
• W2038745440 title "Exosome platform for diagnosis and monitoring of traumatic brain injury" @default.
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