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- W2038760101 abstract "The γ-secretase complex, composed by presenilin, nicastrin, APH-1 and PEN-2, is involved in intramembranous proteolysis of membrane proteins, such as amyloid precursor protein or Notch. Cleavage occurs in multiple cellular compartments. Here, nicastrin mutants containing targeting signals to the endoplasmic reticulum, trans-Golgi network, lysosomes, or plasma membrane have been shown to yield active γ-secretase complexes with different activities and specificities: wild-type and plasma membrane nicastrin complexes yielded the highest amounts of secreted amyloid-β peptide (Aβ), predominantly Aβ40, whereas intracellular targeted mutants produced intracellular Aβ, with a comparatively higher amount of Aβ42. These results suggest that compartmental microenvironments play a role in γ-secretase activity and specificity." @default.
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- W2038760101 date "2004-07-01" @default.
- W2038760101 modified "2023-09-27" @default.
- W2038760101 title "P4-288 Molecular dissection of PEN-2 function in PS1 endoproteolysis and γ-secretase complex formation" @default.
- W2038760101 doi "https://doi.org/10.1016/s0197-4580(04)81846-3" @default.
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