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- W2038761728 abstract "Pathophysiological remodeling processes at an early stage of an acquired epilepsy are critical but not well understood. Therefore, we examined acute changes in action potential (AP) dynamics immediately following status epilepticus (SE) in mice. SE was induced by intraperitoneal (i.p.) injection of kainate, and behavioral manifestation of SE was monitored for 3–4 h. After this time interval CA1 pyramidal cells were studied ex vivo with whole-cell current-clamp and Ca2+ imaging techniques in a hippocampal slice preparation. Following acute SE both resting potential and firing threshold were modestly depolarized (2–5 mV). No changes were seen in input resistance or membrane time constant, but AP latency was prolonged and AP upstroke velocity reduced following acute SE. All cells showed an increase in AP halfwidth and regular (rather than burst) firing, and in a fraction of cells the notch, typically preceding spike afterdepolarization (ADP), was absent following acute SE. Notably, the typical attenuation of backpropagating action potential (b-AP)-induced Ca2+ signals along the apical dendrite was strengthened following acute SE. The effects of acute SE on the retrograde spread of excitation were mimicked by applying the Kv4 current potentiating drug NS5806. Our data unveil a reduced somatodendritic excitability in hippocampal CA1 pyramidal cells immediately after acute SE with a possible involvement of both Na+ and K+ current components." @default.
- W2038761728 created "2016-06-24" @default.
- W2038761728 creator A5009318026 @default.
- W2038761728 creator A5021590823 @default.
- W2038761728 date "2011-10-24" @default.
- W2038761728 modified "2023-10-16" @default.
- W2038761728 title "Acute Alterations of Somatodendritic Action Potential Dynamics in Hippocampal CA1 Pyramidal Cells after Kainate-Induced Status Epilepticus in Mice" @default.
- W2038761728 cites W118553820 @default.
- W2038761728 cites W1549050411 @default.
- W2038761728 cites W1559348600 @default.
- W2038761728 cites W1570612396 @default.
- W2038761728 cites W1600849928 @default.
- W2038761728 cites W162296534 @default.
- W2038761728 cites W1770278459 @default.
- W2038761728 cites W1795010483 @default.
- W2038761728 cites W1868485233 @default.
- W2038761728 cites W1906539094 @default.
- W2038761728 cites W1920883260 @default.
- W2038761728 cites W1963919685 @default.
- W2038761728 cites W1968026088 @default.
- W2038761728 cites W1970425067 @default.
- W2038761728 cites W1971977652 @default.
- W2038761728 cites W1972289901 @default.
- W2038761728 cites W1973988298 @default.
- W2038761728 cites W1974433144 @default.
- W2038761728 cites W1976763631 @default.
- W2038761728 cites W1983021935 @default.
- W2038761728 cites W1983219116 @default.
- W2038761728 cites W1991673195 @default.
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- W2038761728 cites W2017083014 @default.
- W2038761728 cites W2023148260 @default.
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- W2038761728 cites W2065416066 @default.
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- W2038761728 cites W2068805802 @default.
- W2038761728 cites W2075213530 @default.
- W2038761728 cites W2076462587 @default.
- W2038761728 cites W2078832107 @default.
- W2038761728 cites W2085251042 @default.
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- W2038761728 cites W2085957678 @default.
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- W2038761728 cites W2107351696 @default.
- W2038761728 cites W2109124439 @default.
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- W2038761728 cites W2120652370 @default.
- W2038761728 cites W2126274301 @default.
- W2038761728 cites W2127586922 @default.
- W2038761728 cites W2128224468 @default.
- W2038761728 cites W2132593434 @default.
- W2038761728 cites W2133258871 @default.
- W2038761728 cites W2143470172 @default.
- W2038761728 cites W2145517203 @default.
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- W2038761728 cites W2164009595 @default.
- W2038761728 cites W2166447911 @default.
- W2038761728 cites W2169532641 @default.
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- W2038761728 doi "https://doi.org/10.1371/journal.pone.0026664" @default.
- W2038761728 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3200351" @default.
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