Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038767584> ?p ?o ?g. }
- W2038767584 endingPage "e66770" @default.
- W2038767584 startingPage "e66770" @default.
- W2038767584 abstract "We investigated the expression of the secreted frizzled-related proteins (SFRPs) in keratoconus (KC) and control corneas. KC buttons (∼8 mm diameter) (n = 15) and whole control corneas (n = 7) were fixed in 10% formalin or 2% paraformaldehyde and subsequently paraffin embedded and sectioned. Sections for histopathology were stained with hematoxylin and eosin, or Periodic Acid Schiff’s reagent. A series of sections was also immunolabelled with SFRP 1 to 5 antibodies, visualised using immunofluorescence, and examined with a Zeiss LSM700 scanning laser confocal microscope. Semi-quantitative grading was used to compare SFRP immunostaining in KC and control corneas. Overall, KC corneas showed increased immunostaining for SFRP1 to 5, compared to controls. Corneal epithelium in all KC corneas displayed heterogeneous moderate to strong immunoreactivity for SFRP1 to 4, particularly in the basal epithelium adjacent to cone area. SFRP3 and 5 were localised to epithelial cell membranes in KC and control corneas, with increased SFRP3 cytoplasmic expression observed in KC. Strong stromal expression of SFRP5, including extracellular matrix, was seen in both KC and control corneas. In control corneas we observed differential expression of SFRP family proteins in the limbus compared to more central cornea. Taken together, our results support a role for SFRPs in maintaining a healthy cornea and in the pathogenesis of epithelial and anterior stromal disruption observed in KC." @default.
- W2038767584 created "2016-06-24" @default.
- W2038767584 creator A5033215853 @default.
- W2038767584 creator A5037170458 @default.
- W2038767584 creator A5043847188 @default.
- W2038767584 creator A5070288036 @default.
- W2038767584 creator A5077616429 @default.
- W2038767584 date "2013-06-18" @default.
- W2038767584 modified "2023-09-27" @default.
- W2038767584 title "Expression of SFRP Family Proteins in Human Keratoconus Corneas" @default.
- W2038767584 cites W1836265445 @default.
- W2038767584 cites W1852157430 @default.
- W2038767584 cites W1856745672 @default.
- W2038767584 cites W1967354060 @default.
- W2038767584 cites W1970625951 @default.
- W2038767584 cites W1980068428 @default.
- W2038767584 cites W1983638975 @default.
- W2038767584 cites W1983924164 @default.
- W2038767584 cites W1984199402 @default.
- W2038767584 cites W1987690014 @default.
- W2038767584 cites W1993359253 @default.
- W2038767584 cites W2003944206 @default.
- W2038767584 cites W2023329572 @default.
- W2038767584 cites W2024527973 @default.
- W2038767584 cites W2028372431 @default.
- W2038767584 cites W2032172453 @default.
- W2038767584 cites W2032459358 @default.
- W2038767584 cites W2038658448 @default.
- W2038767584 cites W2039396493 @default.
- W2038767584 cites W2040723131 @default.
- W2038767584 cites W2045883614 @default.
- W2038767584 cites W2053379997 @default.
- W2038767584 cites W2053395922 @default.
- W2038767584 cites W2054351923 @default.
- W2038767584 cites W2060735685 @default.
- W2038767584 cites W2062484117 @default.
- W2038767584 cites W2063244555 @default.
- W2038767584 cites W2077317914 @default.
- W2038767584 cites W2079819294 @default.
- W2038767584 cites W2081005330 @default.
- W2038767584 cites W2081241334 @default.
- W2038767584 cites W2082311506 @default.
- W2038767584 cites W2106330601 @default.
- W2038767584 cites W2106878382 @default.
- W2038767584 cites W2109927917 @default.
- W2038767584 cites W2119284420 @default.
- W2038767584 cites W2121844692 @default.
- W2038767584 cites W2137898020 @default.
- W2038767584 cites W2140460495 @default.
- W2038767584 cites W2152567646 @default.
- W2038767584 cites W2155568793 @default.
- W2038767584 cites W4210991337 @default.
- W2038767584 doi "https://doi.org/10.1371/journal.pone.0066770" @default.
- W2038767584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3688946" @default.
- W2038767584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23825088" @default.
- W2038767584 hasPublicationYear "2013" @default.
- W2038767584 type Work @default.
- W2038767584 sameAs 2038767584 @default.
- W2038767584 citedByCount "15" @default.
- W2038767584 countsByYear W20387675842015 @default.
- W2038767584 countsByYear W20387675842017 @default.
- W2038767584 countsByYear W20387675842018 @default.
- W2038767584 countsByYear W20387675842019 @default.
- W2038767584 countsByYear W20387675842020 @default.
- W2038767584 countsByYear W20387675842021 @default.
- W2038767584 countsByYear W20387675842022 @default.
- W2038767584 crossrefType "journal-article" @default.
- W2038767584 hasAuthorship W2038767584A5033215853 @default.
- W2038767584 hasAuthorship W2038767584A5037170458 @default.
- W2038767584 hasAuthorship W2038767584A5043847188 @default.
- W2038767584 hasAuthorship W2038767584A5070288036 @default.
- W2038767584 hasAuthorship W2038767584A5077616429 @default.
- W2038767584 hasBestOaLocation W20387675841 @default.
- W2038767584 hasConcept C105702510 @default.
- W2038767584 hasConcept C142724271 @default.
- W2038767584 hasConcept C153911025 @default.
- W2038767584 hasConcept C16930146 @default.
- W2038767584 hasConcept C169760540 @default.
- W2038767584 hasConcept C189165786 @default.
- W2038767584 hasConcept C204232928 @default.
- W2038767584 hasConcept C2776193487 @default.
- W2038767584 hasConcept C2776882836 @default.
- W2038767584 hasConcept C2778723968 @default.
- W2038767584 hasConcept C2778918178 @default.
- W2038767584 hasConcept C2779257441 @default.
- W2038767584 hasConcept C4224716 @default.
- W2038767584 hasConcept C529295009 @default.
- W2038767584 hasConcept C71924100 @default.
- W2038767584 hasConcept C86803240 @default.
- W2038767584 hasConcept C95444343 @default.
- W2038767584 hasConceptScore W2038767584C105702510 @default.
- W2038767584 hasConceptScore W2038767584C142724271 @default.
- W2038767584 hasConceptScore W2038767584C153911025 @default.
- W2038767584 hasConceptScore W2038767584C16930146 @default.
- W2038767584 hasConceptScore W2038767584C169760540 @default.
- W2038767584 hasConceptScore W2038767584C189165786 @default.
- W2038767584 hasConceptScore W2038767584C204232928 @default.
- W2038767584 hasConceptScore W2038767584C2776193487 @default.