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- W2038770083 endingPage "589" @default.
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- W2038770083 abstract "Sinefungin, an antifungal and antiparasitic nucleoside antibiotic, is a very potent antileishmanial agent both in vitro and in vivo. This molecule, structurally related to S-adenosylmethionine, is a good competitive inhibitor of methyltransferases in vitro. The aim of this report is to analyze the impact of sinefungin on methylation pattern and the subcellular localisation of methyl groups and various methylases in promastigotes of Leishmania donovani. We have shown the presence of various methylated macromolecules in different subcellular fractions, with somewhat higher concentration in membrane fraction. In vitro, sinefungin inhibits the three main protein methylases, but in cells cultured in its presence the protein carboxylmethylations are specifically inhibited." @default.
- W2038770083 created "2016-06-24" @default.
- W2038770083 creator A5037699768 @default.
- W2038770083 creator A5063888461 @default.
- W2038770083 date "1993-09-01" @default.
- W2038770083 modified "2023-10-18" @default.
- W2038770083 title "Distribution of Macromolecular Methylations in Promastigotes of Leishmania donovani and Impact of Sinefungin" @default.
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- W2038770083 doi "https://doi.org/10.1111/j.1550-7408.1993.tb06111.x" @default.
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