FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038772178> ?p ?o ?g. }

• W2038772178 endingPage "58" @default.
• W2038772178 startingPage "49" @default.
• W2038772178 abstract "BACKGROUND The estramustine binding protein (EMBP) specifically binds to estramustine and was first discovered in the rat ventral prostate. However, the physiological property of EMBP in the human prostate still remains to be elucidated. To elucidate whether EMBP is interrelated with cellular proliferation in human prostatic carcinoma (PC), the change in EMBP immunostaining during luteinizing hormone-releasing hormone (LH-RH) analog administration or during Cis-platinum-based chemotherapy, and the difference in EMBP immunostaining between hormone refractory (hr-PC) and untreated PC were analyzed. METHODS Forty-six patients with histologically proven untreated PCs (34 were treated with LH-RH analog and 12 were treated with chemotherapy as an initial therapy) and 14 with hr-PC were used in this study. PC tissues were obtained before and 3 months after the initial therapy. The changes in immunostainings for EMBP, proliferating cell nuclear antigen (PCNA), and nm23 protein were compared with the change in serum prostate-specific antigen (PSA) level and the histological response during the treatment. RESULTS The increased EMBP expression was observed in tumors with high histological grade and high clinical stage as well as in hr-PC. In untreated PC, EMBP expression weakly correlated with PCNA or nm23 protein immunoreactivity. In PC receiving LH-RH analog, EMBP expression was significantly reduced after treatment, however, no significant changes were observed in PCNA or nm23 protein immunoreactivity. In addition, EMBP expression before the treatment significantly correlated with the serum PSA change, while PCNA expression and nm23 protein immunoreactivity did not. On the other hand, no significant relationship was observed between histological changes induced by the LH-RH analog and immunostainings for EMBP, PCNA, and nm23 protein before treatment. In PC patients receiving chemotherapy, immunostainings for EMBP, PCNA, and nm23 protein were not significantly changed during the treatment. EMBP immunoreactivity was significantly higher in hr-PC than in untreated PC with paralleled change of PCNA expression and nm23 protein immunoreactivity. CONCLUSIONS These observations indicate that EMBP is androgen regulated in some PCs. However, EMBP expression is demonstrated even in hr-PC and is interrelated with cellular proliferation especially in hr-PC. Prostate 32:49–58, 1997. © Wiley-Liss, Inc." @default.
• W2038772178 created "2016-06-24" @default.
• W2038772178 creator A5002595315 @default.
• W2038772178 creator A5003006585 @default.
• W2038772178 creator A5006428732 @default.
• W2038772178 creator A5007827334 @default.
• W2038772178 creator A5009040773 @default.
• W2038772178 creator A5018531480 @default.
• W2038772178 creator A5036097429 @default.
• W2038772178 creator A5045996236 @default.
• W2038772178 creator A5058077375 @default.
• W2038772178 creator A5066905885 @default.
• W2038772178 creator A5076320235 @default.
• W2038772178 date "1997-06-15" @default.
• W2038772178 modified "2023-09-26" @default.
• W2038772178 title "Immunohistochemical analysis of estramustine binding protein with particular reference to proliferative activity in human prostatic carcinoma" @default.
• W2038772178 cites W1616748355 @default.
• W2038772178 cites W1964390756 @default.
• W2038772178 cites W1974012433 @default.
• W2038772178 cites W1975090494 @default.
• W2038772178 cites W1984517237 @default.
• W2038772178 cites W1986446031 @default.
• W2038772178 cites W1994099444 @default.
• W2038772178 cites W2002538042 @default.
• W2038772178 cites W2007599495 @default.
• W2038772178 cites W2020207377 @default.
• W2038772178 cites W2029440030 @default.
• W2038772178 cites W2031022076 @default.
• W2038772178 cites W2034128373 @default.
• W2038772178 cites W2039626021 @default.
• W2038772178 cites W2053717292 @default.
• W2038772178 cites W2061322405 @default.
• W2038772178 cites W2062626332 @default.
• W2038772178 cites W2066712014 @default.
• W2038772178 cites W2079200980 @default.
• W2038772178 cites W2079586917 @default.
• W2038772178 cites W2112336468 @default.
• W2038772178 cites W2142429523 @default.
• W2038772178 cites W2162805000 @default.
• W2038772178 cites W2163976338 @default.
• W2038772178 cites W2321580420 @default.
• W2038772178 cites W2396982863 @default.
• W2038772178 cites W2412651756 @default.
• W2038772178 cites W2417667084 @default.
• W2038772178 cites W2474424080 @default.
• W2038772178 cites W2036744671 @default.
• W2038772178 doi "https://doi.org/10.1002/(sici)1097-0045(19970615)32:1<49::aid-pros7>3.0.co;2-7" @default.
• W2038772178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9207957" @default.
• W2038772178 hasPublicationYear "1997" @default.
• W2038772178 type Work @default.
• W2038772178 sameAs 2038772178 @default.
• W2038772178 citedByCount "6" @default.
• W2038772178 crossrefType "journal-article" @default.
• W2038772178 hasAuthorship W2038772178A5002595315 @default.
• W2038772178 hasAuthorship W2038772178A5003006585 @default.
• W2038772178 hasAuthorship W2038772178A5006428732 @default.
• W2038772178 hasAuthorship W2038772178A5007827334 @default.
• W2038772178 hasAuthorship W2038772178A5009040773 @default.
• W2038772178 hasAuthorship W2038772178A5018531480 @default.
• W2038772178 hasAuthorship W2038772178A5036097429 @default.
• W2038772178 hasAuthorship W2038772178A5045996236 @default.
• W2038772178 hasAuthorship W2038772178A5058077375 @default.
• W2038772178 hasAuthorship W2038772178A5066905885 @default.
• W2038772178 hasAuthorship W2038772178A5076320235 @default.
• W2038772178 hasConcept C121608353 @default.
• W2038772178 hasConcept C126322002 @default.
• W2038772178 hasConcept C134018914 @default.
• W2038772178 hasConcept C142724271 @default.
• W2038772178 hasConcept C147483822 @default.
• W2038772178 hasConcept C203014093 @default.
• W2038772178 hasConcept C204232928 @default.
• W2038772178 hasConcept C2776235491 @default.
• W2038772178 hasConcept C2776694085 @default.
• W2038772178 hasConcept C2777546739 @default.
• W2038772178 hasConcept C2780201970 @default.
• W2038772178 hasConcept C2994223898 @default.
• W2038772178 hasConcept C34688535 @default.
• W2038772178 hasConcept C4224716 @default.
• W2038772178 hasConcept C502942594 @default.
• W2038772178 hasConcept C71924100 @default.
• W2038772178 hasConcept C86803240 @default.
• W2038772178 hasConceptScore W2038772178C121608353 @default.
• W2038772178 hasConceptScore W2038772178C126322002 @default.
• W2038772178 hasConceptScore W2038772178C134018914 @default.
• W2038772178 hasConceptScore W2038772178C142724271 @default.
• W2038772178 hasConceptScore W2038772178C147483822 @default.
• W2038772178 hasConceptScore W2038772178C203014093 @default.
• W2038772178 hasConceptScore W2038772178C204232928 @default.
• W2038772178 hasConceptScore W2038772178C2776235491 @default.
• W2038772178 hasConceptScore W2038772178C2776694085 @default.
• W2038772178 hasConceptScore W2038772178C2777546739 @default.
• W2038772178 hasConceptScore W2038772178C2780201970 @default.
• W2038772178 hasConceptScore W2038772178C2994223898 @default.
• W2038772178 hasConceptScore W2038772178C34688535 @default.
• W2038772178 hasConceptScore W2038772178C4224716 @default.
• W2038772178 hasConceptScore W2038772178C502942594 @default.
• W2038772178 hasConceptScore W2038772178C71924100 @default.
• W2038772178 hasConceptScore W2038772178C86803240 @default.

• next