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- W2038777523 abstract "As demonstrated in the preceding paper, normal bile has a significant in-hibitory effect on bacterial β-glucuronidase which is known to play an important role in the development of calcium bilirubinate stones. To elucidate the pheno-menon, a number of substances that are generally accepted as bile constituents were independently examined for the effect on the activity of bacterial β-glucuronidase. It was then revealed that fatty acids, lecithin, cholesterol and inorganic ions except Cu++ did not influence the enzyme activity. Bile acids inhibited the activity of a commercial preparation of this enzyme but rather activated bacterial β-glucuronidase of infected bile. Free bilirubin as well as glucuronic acid exhibited a considerable inhibitory power only at a concentration exceeding the actual concentration in normal bile. Cu++ inhibited the enzyme activity at a concentration near the normal Cu content of bile, but there was no significant correlation between the Cu content and the inhibitory power of normal bile specimens. The results thus seem to suggest that bile includes a strong inhibitor of this enzyme which has not yet been identified as a normal constituent of bile." @default.
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- W2038777523 date "1965-01-01" @default.
- W2038777523 modified "2023-09-24" @default.
- W2038777523 title "Effect of Known Constituents of Bile on the Activity of Bacterial β-Glucuronidase" @default.
- W2038777523 doi "https://doi.org/10.1620/tjem.85.210" @default.
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