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- W2038785602 abstract "Guidelines for the management of individuals with a high risk of cancer due to an identified gene mutation or their family history include recommendations for intensive surveillance programmes and risk-reducing strategies. Although dependent on the cancer and the particular risk-reducing strategy (eg, screening colonoscopy in Lynch syndrome, and bilateral salpingo-oophorectomy in carriers of BRCA1 or BRCA2 mutations), adherence to the screening test or uptake of surgery results in well documented reductions in cancer incidence and mortality. 1 Jarvinen HJ Aarnio M Surveillance on mutation carriers of DNA mismatch repair genes. Ann Chir Gynaecol. 2000; 89: 207-210 PubMed Google Scholar , 2 Rebbeck TR Kauff ND Domchek SM Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers. J Natl Cancer Inst. 2009; 101: 80-87 Crossref PubMed Scopus (650) Google Scholar Adherence to screening is variable, but of concern, uptake of risk-reducing strategies remains low in carriers of BRCA1 or BRCA2 in Australia. 3 Antill Y Reynolds J Young MA et al. Risk-reducing surgery in women with familial susceptibility for breast and/or ovarian cancer. Eur J Cancer. 2006; 42: 621-628 Summary Full Text Full Text PDF PubMed Scopus (36) Google Scholar , 4 Collins I M R, Weideman P, McLachlan SA, et al. Risk-reducing behaviour of female BRCA1 and BRCA2 mutation carriers; long-term follow-up of participants in kConFab. Medical Oncology Group of Australia Annual Scientific Meeting 2013; Melbourne, VIC; July 31–Aug 2, 2013. Google Scholar Potential barriers to uptake might include public hospital waiting times. With the health dollar stretched in many directions, and the scrutiny of current health-care provision under the umbrella of a newly elected Australian Government, it seems timely to look at some of the issues facing patients at high risk of developing a malignancy." @default.
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- W2038785602 date "2013-11-01" @default.
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- W2038785602 title "Waiting for prevention in Australia" @default.
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- W2038785602 doi "https://doi.org/10.1016/s1470-2045(13)70439-x" @default.
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