Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038788983> ?p ?o ?g. }
- W2038788983 endingPage "81" @default.
- W2038788983 startingPage "75" @default.
- W2038788983 abstract "Abstract The combination of hydroxyapatite (HA) implants serving as osteoconductive scaffold with growth factors is an interesting approach for the improvement of bone defect healing. The purpose of this study was to test whether recombinant human bone morphogenetic protein‐2 (rhBMP‐2) coating of solid HA‐implants improves bone formation in a cortical bone defect. Cylindrical trephine mill defects (diameter: 9.8 mm, depth: 10 mm) were created into the cortical tibia shaft of minipigs and subsequently filled either by plain HA cylinders (Endobon®) or by rhBMP‐2‐coated HA cylinders. Fluorochrome labeling for the evaluation of time‐dependent bone formation was done on days 8, 9, and 10 postsurgery with tetracyclin‐100, at days 25 and 30 with alizarin‐komplexon, and finally on days 32, 37, 73, and 79 with calcein green. Twelve weeks after implantation, the tibiae were harvested and were prepared for standard histological staining, fluorochrome analysis, and histomorphometry. Coating of HA implants with rhBMP‐2 led to significant enhanced new bone formation of 84.7% (±4.6%) of the implant area with almost complete bony incorporation compared with only 27.7% (±8.5%) in the uncoated HA implants ( p = 0.028). In both types of implants, osteoconduction of HA led to bone ingrowth of the surrounding host bone into the implants. However, only rhBMP‐2‐coated implants showed multitopic de novo bone formation reflecting the osteoinductive properties of rhBMP‐2 in all areas of the HA implant. This study showed that the coating of HA ceramic implants with rhBMP‐2 can significantly enhance new bone formation attributable to its osteoinductive effects. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009" @default.
- W2038788983 created "2016-06-24" @default.
- W2038788983 creator A5003376279 @default.
- W2038788983 creator A5004420044 @default.
- W2038788983 creator A5035873594 @default.
- W2038788983 creator A5039776940 @default.
- W2038788983 creator A5042814312 @default.
- W2038788983 creator A5043380675 @default.
- W2038788983 creator A5066377578 @default.
- W2038788983 creator A5067131015 @default.
- W2038788983 date "2008-11-18" @default.
- W2038788983 modified "2023-10-10" @default.
- W2038788983 title "Enhancement of bone formation in hydroxyapatite implants by rhBMP-2 coating" @default.
- W2038788983 cites W1562125623 @default.
- W2038788983 cites W1964559802 @default.
- W2038788983 cites W1968822620 @default.
- W2038788983 cites W1971113558 @default.
- W2038788983 cites W1972137690 @default.
- W2038788983 cites W1986469118 @default.
- W2038788983 cites W1989251966 @default.
- W2038788983 cites W1992026716 @default.
- W2038788983 cites W1999829265 @default.
- W2038788983 cites W2010567084 @default.
- W2038788983 cites W2015756029 @default.
- W2038788983 cites W2018820156 @default.
- W2038788983 cites W2032724589 @default.
- W2038788983 cites W2058277271 @default.
- W2038788983 cites W2059846465 @default.
- W2038788983 cites W2062236735 @default.
- W2038788983 cites W2075917180 @default.
- W2038788983 cites W2089329099 @default.
- W2038788983 cites W2111109632 @default.
- W2038788983 cites W2117115638 @default.
- W2038788983 cites W2134968806 @default.
- W2038788983 cites W2144825002 @default.
- W2038788983 cites W2148536739 @default.
- W2038788983 cites W2163162846 @default.
- W2038788983 cites W2318779745 @default.
- W2038788983 cites W3000473592 @default.
- W2038788983 cites W4253001208 @default.
- W2038788983 cites W4376848429 @default.
- W2038788983 doi "https://doi.org/10.1002/jbm.b.31255" @default.
- W2038788983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19016453" @default.
- W2038788983 hasPublicationYear "2008" @default.
- W2038788983 type Work @default.
- W2038788983 sameAs 2038788983 @default.
- W2038788983 citedByCount "13" @default.
- W2038788983 countsByYear W20387889832012 @default.
- W2038788983 countsByYear W20387889832013 @default.
- W2038788983 countsByYear W20387889832015 @default.
- W2038788983 countsByYear W20387889832017 @default.
- W2038788983 countsByYear W20387889832019 @default.
- W2038788983 countsByYear W20387889832020 @default.
- W2038788983 countsByYear W20387889832021 @default.
- W2038788983 countsByYear W20387889832022 @default.
- W2038788983 crossrefType "journal-article" @default.
- W2038788983 hasAuthorship W2038788983A5003376279 @default.
- W2038788983 hasAuthorship W2038788983A5004420044 @default.
- W2038788983 hasAuthorship W2038788983A5035873594 @default.
- W2038788983 hasAuthorship W2038788983A5039776940 @default.
- W2038788983 hasAuthorship W2038788983A5042814312 @default.
- W2038788983 hasAuthorship W2038788983A5043380675 @default.
- W2038788983 hasAuthorship W2038788983A5066377578 @default.
- W2038788983 hasAuthorship W2038788983A5067131015 @default.
- W2038788983 hasConcept C105702510 @default.
- W2038788983 hasConcept C134018914 @default.
- W2038788983 hasConcept C136229726 @default.
- W2038788983 hasConcept C141071460 @default.
- W2038788983 hasConcept C185592680 @default.
- W2038788983 hasConcept C192562407 @default.
- W2038788983 hasConcept C199343813 @default.
- W2038788983 hasConcept C202751555 @default.
- W2038788983 hasConcept C2776232749 @default.
- W2038788983 hasConcept C2776872141 @default.
- W2038788983 hasConcept C2777236700 @default.
- W2038788983 hasConcept C2781411149 @default.
- W2038788983 hasConcept C2993291840 @default.
- W2038788983 hasConcept C30352789 @default.
- W2038788983 hasConcept C41625074 @default.
- W2038788983 hasConcept C55493867 @default.
- W2038788983 hasConcept C71924100 @default.
- W2038788983 hasConcept C89429830 @default.
- W2038788983 hasConceptScore W2038788983C105702510 @default.
- W2038788983 hasConceptScore W2038788983C134018914 @default.
- W2038788983 hasConceptScore W2038788983C136229726 @default.
- W2038788983 hasConceptScore W2038788983C141071460 @default.
- W2038788983 hasConceptScore W2038788983C185592680 @default.
- W2038788983 hasConceptScore W2038788983C192562407 @default.
- W2038788983 hasConceptScore W2038788983C199343813 @default.
- W2038788983 hasConceptScore W2038788983C202751555 @default.
- W2038788983 hasConceptScore W2038788983C2776232749 @default.
- W2038788983 hasConceptScore W2038788983C2776872141 @default.
- W2038788983 hasConceptScore W2038788983C2777236700 @default.
- W2038788983 hasConceptScore W2038788983C2781411149 @default.
- W2038788983 hasConceptScore W2038788983C2993291840 @default.
- W2038788983 hasConceptScore W2038788983C30352789 @default.
- W2038788983 hasConceptScore W2038788983C41625074 @default.
- W2038788983 hasConceptScore W2038788983C55493867 @default.