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- W2038789545 abstract "Abstract Thromboxane A 2 (TXA 2 ) synthesis during factor VIII/von Willebrand factor (FVIII/vWF) induced-platelet aggregation was studied in human platelets prelabeled with (1- 14 C)-arachidonic acid ( 14 C-AA). Although previous studies demonstrate that thrombin, collagen or epinephrine induced platelet aggregation is associated with TXA 2 synthesis, no TXA 2 synthesis was detected in FVIII/vWF induced aggregation. Nevertheless, an increased release of 14 C-AA and its probable conversion into HETE was detected during platelet aggregation induced by FVIII/vWF in the presence of ristocetin. When thrombin was added to 14 C-AA labeled platelet suspensions, similar amounts of TXA 2 were synthesized with or without stirring, despite the fact that no platelet aggregation occurs without stirring. These results indicate that TXA 2 is not synthesized during FVIII/vWF induced platelet aggregation, and that aggregation of platelets is not a pre-requisite for TXA 2 synthesis." @default.
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- W2038789545 date "1981-11-01" @default.
- W2038789545 modified "2023-10-16" @default.
- W2038789545 title "Lack of thromboxane A2 synthesis in platelet aggregation induced by factor VIII/von willebrand factor" @default.
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- W2038789545 doi "https://doi.org/10.1016/0049-3848(81)90094-3" @default.
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