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- W2038802102 endingPage "S27" @default.
- W2038802102 startingPage "S13" @default.
- W2038802102 abstract "This paper will review clinical pharmacology studies on buprenorphine, a mixed opioid agonist-antagonist currently approved as a treatment for opioid dependence. The focus is on studies characterizing buprenorphine's pharmacodynamic actions, including its safety, abuse liability, withdrawal suppression and withdrawal precipitation capacity, physical dependence potential, cross-tolerance and duration of action as well as a review of the pharmacological profile of buprenorphine/naloxone combinations. The findings from these clinical pharmacology studies are synthesized and presented in a framework designed to (1) inform clinicians about the advantages and disadvantages of buprenorphine as an opioid maintenance agent, and (2) provide information about dosing procedures that may optimize the use of buprenorphine in the clinic." @default.
- W2038802102 created "2016-06-24" @default.
- W2038802102 creator A5021278551 @default.
- W2038802102 creator A5064551545 @default.
- W2038802102 date "2003-05-01" @default.
- W2038802102 modified "2023-10-14" @default.
- W2038802102 title "The clinical pharmacology of buprenorphine: extrapolating from the laboratory to the clinic" @default.
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- W2038802102 doi "https://doi.org/10.1016/s0376-8716(03)00056-5" @default.
- W2038802102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12738347" @default.
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