Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038803062> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2038803062 endingPage "473" @default.
- W2038803062 startingPage "465" @default.
- W2038803062 abstract "As obese Zucker rats (OZR) manifesting the metabolic syndrome exhibit enhanced vascular adrenergic constriction and potentially an enhanced adrenergic activity vs. lean Zucker rats (LZR), this study tested the hypothesis that OZR exhibit an improved tolerance to progressive hemorrhage. Preliminary experiments indicated that, corrected for body mass, total blood volume was reduced in OZR vs. LZR. Anesthetized LZR and OZR had a cremaster muscle prepared for in situ videomicroscopy and had renal, splanchnic, hindlimb, and skeletal muscle perfusion monitored with flow probes. Arterial pressure, arteriolar reactivity to norepinephrine, and tissue/organ perfusion were monitored after either infusion of phentolamine or successive withdrawals of 10% total blood volume. Phentolamine infusion indicated that regional adrenergic tone under control conditions differs substantially between LZR and OZR, whereas with hemorrhage OZR exhibit decompensation in arterial pressure before LZR. Renal, distal hindlimb, and skeletal muscle perfusion decreased more rapidly and to a greater extent in OZR vs. LZR after hemorrhage. In contrast, hemorrhage-induced reductions in splanchnic perfusion in OZR lagged behind those in LZR, although a similar maximum reduction was ultimately attained. With increasing hemorrhage, cremasteric arteriolar tone increased more in OZR than LZR, and this increase in active tone was entirely due to an elevated adrenergic contribution. Norepinephrine-induced arteriolar constriction was greater in OZR vs. LZR under control conditions and during hemorrhage, with arterioles from OZR demonstrating early closure vs. LZR. These results suggest that a combination of reduced blood volume and elevated peripheral adrenergic constriction contribute to impaired hemorrhage tolerance in OZR." @default.
- W2038803062 created "2016-06-24" @default.
- W2038803062 creator A5000886546 @default.
- W2038803062 date "2006-02-01" @default.
- W2038803062 modified "2023-09-27" @default.
- W2038803062 title "Impaired hemorrhage tolerance in the obese Zucker rat model of metabolic syndrome" @default.
- W2038803062 cites W1983253057 @default.
- W2038803062 cites W2025481166 @default.
- W2038803062 cites W2030030872 @default.
- W2038803062 cites W2050772837 @default.
- W2038803062 cites W2051676242 @default.
- W2038803062 cites W2053482074 @default.
- W2038803062 cites W2054328482 @default.
- W2038803062 cites W2076424604 @default.
- W2038803062 cites W2099021486 @default.
- W2038803062 cites W2114920731 @default.
- W2038803062 cites W2131716859 @default.
- W2038803062 cites W2133949509 @default.
- W2038803062 cites W2147770931 @default.
- W2038803062 cites W2147945311 @default.
- W2038803062 cites W2150342600 @default.
- W2038803062 cites W2150965443 @default.
- W2038803062 cites W2168536185 @default.
- W2038803062 cites W2171029820 @default.
- W2038803062 cites W2413344286 @default.
- W2038803062 cites W4210956151 @default.
- W2038803062 doi "https://doi.org/10.1152/japplphysiol.01062.2005" @default.
- W2038803062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16223976" @default.
- W2038803062 hasPublicationYear "2006" @default.
- W2038803062 type Work @default.
- W2038803062 sameAs 2038803062 @default.
- W2038803062 citedByCount "23" @default.
- W2038803062 countsByYear W20388030622012 @default.
- W2038803062 countsByYear W20388030622013 @default.
- W2038803062 countsByYear W20388030622014 @default.
- W2038803062 countsByYear W20388030622015 @default.
- W2038803062 countsByYear W20388030622016 @default.
- W2038803062 countsByYear W20388030622017 @default.
- W2038803062 countsByYear W20388030622018 @default.
- W2038803062 countsByYear W20388030622019 @default.
- W2038803062 countsByYear W20388030622020 @default.
- W2038803062 countsByYear W20388030622023 @default.
- W2038803062 crossrefType "journal-article" @default.
- W2038803062 hasAuthorship W2038803062A5000886546 @default.
- W2038803062 hasConcept C126322002 @default.
- W2038803062 hasConcept C134018914 @default.
- W2038803062 hasConcept C146957229 @default.
- W2038803062 hasConcept C158453852 @default.
- W2038803062 hasConcept C170493617 @default.
- W2038803062 hasConcept C178853913 @default.
- W2038803062 hasConcept C185592680 @default.
- W2038803062 hasConcept C2775849017 @default.
- W2038803062 hasConcept C71924100 @default.
- W2038803062 hasConceptScore W2038803062C126322002 @default.
- W2038803062 hasConceptScore W2038803062C134018914 @default.
- W2038803062 hasConceptScore W2038803062C146957229 @default.
- W2038803062 hasConceptScore W2038803062C158453852 @default.
- W2038803062 hasConceptScore W2038803062C170493617 @default.
- W2038803062 hasConceptScore W2038803062C178853913 @default.
- W2038803062 hasConceptScore W2038803062C185592680 @default.
- W2038803062 hasConceptScore W2038803062C2775849017 @default.
- W2038803062 hasConceptScore W2038803062C71924100 @default.
- W2038803062 hasIssue "2" @default.
- W2038803062 hasLocation W20388030621 @default.
- W2038803062 hasLocation W20388030622 @default.
- W2038803062 hasOpenAccess W2038803062 @default.
- W2038803062 hasPrimaryLocation W20388030621 @default.
- W2038803062 hasRelatedWork W1969630931 @default.
- W2038803062 hasRelatedWork W1976234278 @default.
- W2038803062 hasRelatedWork W2052453588 @default.
- W2038803062 hasRelatedWork W2058478536 @default.
- W2038803062 hasRelatedWork W2081447879 @default.
- W2038803062 hasRelatedWork W2117608793 @default.
- W2038803062 hasRelatedWork W2146118393 @default.
- W2038803062 hasRelatedWork W2150937124 @default.
- W2038803062 hasRelatedWork W2748952813 @default.
- W2038803062 hasRelatedWork W287203130 @default.
- W2038803062 hasVolume "100" @default.
- W2038803062 isParatext "false" @default.
- W2038803062 isRetracted "false" @default.
- W2038803062 magId "2038803062" @default.
- W2038803062 workType "article" @default.