FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038804536> ?p ?o ?g. }

• W2038804536 abstract "Excessive burst firing in the dopamine-depleted basal ganglia correlates with severe motor symptoms of Parkinson's disease that are attenuated by high frequency electrical stimulation of the subthalamic nucleus (STN). Here we test the hypothesis that pathological bursts in dopamine-deprived basal ganglia are generated within the STN and transmitted to globus pallidus neurons. To answer this question we recorded excitatory synaptic currents and potentials from subthalamic and pallidal neurons in the basal ganglia slice (BGS) from dopamine-depleted mice while continuously blocking GABA(A) receptors. In control mice, a single electrical stimulus delivered to the internal capsule or the rostral pole of the STN evoked a short duration, small amplitude, monosynaptic EPSC in subthalamic neurons. In contrast, in the dopamine-depleted BGS, this monosynaptic EPSC was amplified and followed by a burst of polysynaptic EPSCs that eventually reverberated three to seven times, providing a long lasting response that gave rise to bursts of EPSCs and spikes in GP neurons. Repetitive (10-120 Hz) stimulation delivered to the STN in the dopamine-depleted BGS attenuated STN-evoked bursts of EPSCs in pallidal neurons after several minutes of stimulation but only high frequency (90-120 Hz) stimulation replaced them with small amplitude EPSCs at 20 Hz. We propose that the polysynaptic pathway within the STN amplifies subthalamic responses to incoming excitation in the dopamine-depleted basal ganglia, thereby transforming the STN into a burst generator and entraining pallidal neurons in pathogenic bursting activities. High frequency stimulation of the STN prevents the transmission of this pathological activity to globus pallidus and imposes a new glutamatergic synaptic noise on pallidal neurons." @default.
• W2038804536 created "2016-06-24" @default.
• W2038804536 creator A5014491536 @default.
• W2038804536 creator A5032794342 @default.
• W2038804536 creator A5061731233 @default.
• W2038804536 creator A5082108657 @default.
• W2038804536 date "2011-01-01" @default.
• W2038804536 modified "2023-10-07" @default.
• W2038804536 title "The Subthalamic Nucleus becomes a Generator of Bursts in the Dopamine-Depleted State. Its High Frequency Stimulation Dramatically Weakens Transmission to the Globus Pallidus" @default.
• W2038804536 cites W1510554078 @default.
• W2038804536 cites W1548990049 @default.
• W2038804536 cites W1551292361 @default.
• W2038804536 cites W1570789308 @default.
• W2038804536 cites W1597836184 @default.
• W2038804536 cites W1601584365 @default.
• W2038804536 cites W1606921330 @default.
• W2038804536 cites W1768450208 @default.
• W2038804536 cites W186864987 @default.
• W2038804536 cites W1887448744 @default.
• W2038804536 cites W1909924204 @default.
• W2038804536 cites W1928463227 @default.
• W2038804536 cites W1965217635 @default.
• W2038804536 cites W1966199630 @default.
• W2038804536 cites W1973670737 @default.
• W2038804536 cites W1976452441 @default.
• W2038804536 cites W1982014300 @default.
• W2038804536 cites W1982843701 @default.
• W2038804536 cites W1989619740 @default.
• W2038804536 cites W2002572432 @default.
• W2038804536 cites W2003179182 @default.
• W2038804536 cites W2006414608 @default.
• W2038804536 cites W2015166641 @default.
• W2038804536 cites W2015290558 @default.
• W2038804536 cites W2022520344 @default.
• W2038804536 cites W2024154387 @default.
• W2038804536 cites W2028280452 @default.
• W2038804536 cites W2034729932 @default.
• W2038804536 cites W2038406695 @default.
• W2038804536 cites W2051505122 @default.
• W2038804536 cites W2051572005 @default.
• W2038804536 cites W2052689693 @default.
• W2038804536 cites W2052785594 @default.
• W2038804536 cites W2054636893 @default.
• W2038804536 cites W2056710691 @default.
• W2038804536 cites W2057584841 @default.
• W2038804536 cites W2069626472 @default.
• W2038804536 cites W2072023591 @default.
• W2038804536 cites W2083932518 @default.
• W2038804536 cites W2085877827 @default.
• W2038804536 cites W2096875305 @default.
• W2038804536 cites W2101436214 @default.
• W2038804536 cites W2103310955 @default.
• W2038804536 cites W2113908640 @default.
• W2038804536 cites W2119870832 @default.
• W2038804536 cites W2122862649 @default.
• W2038804536 cites W2123208606 @default.
• W2038804536 cites W2125653203 @default.
• W2038804536 cites W2126490942 @default.
• W2038804536 cites W2128252931 @default.
• W2038804536 cites W2136682365 @default.
• W2038804536 cites W2150135821 @default.
• W2038804536 cites W2164295765 @default.
• W2038804536 cites W2165618729 @default.
• W2038804536 cites W2171601518 @default.
• W2038804536 cites W2233714506 @default.
• W2038804536 cites W2236727941 @default.
• W2038804536 doi "https://doi.org/10.3389/fnsys.2011.00043" @default.
• W2038804536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3115486" @default.
• W2038804536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21716635" @default.
• W2038804536 hasPublicationYear "2011" @default.
• W2038804536 type Work @default.
• W2038804536 sameAs 2038804536 @default.
• W2038804536 citedByCount "35" @default.
• W2038804536 countsByYear W20388045362012 @default.
• W2038804536 countsByYear W20388045362013 @default.
• W2038804536 countsByYear W20388045362014 @default.
• W2038804536 countsByYear W20388045362015 @default.
• W2038804536 countsByYear W20388045362017 @default.
• W2038804536 countsByYear W20388045362019 @default.
• W2038804536 countsByYear W20388045362020 @default.
• W2038804536 countsByYear W20388045362022 @default.
• W2038804536 countsByYear W20388045362023 @default.
• W2038804536 crossrefType "journal-article" @default.
• W2038804536 hasAuthorship W2038804536A5014491536 @default.
• W2038804536 hasAuthorship W2038804536A5032794342 @default.
• W2038804536 hasAuthorship W2038804536A5061731233 @default.
• W2038804536 hasAuthorship W2038804536A5082108657 @default.
• W2038804536 hasBestOaLocation W20388045361 @default.
• W2038804536 hasConcept C112592302 @default.
• W2038804536 hasConcept C126322002 @default.
• W2038804536 hasConcept C169760540 @default.
• W2038804536 hasConcept C170493617 @default.
• W2038804536 hasConcept C17077164 @default.
• W2038804536 hasConcept C195221683 @default.
• W2038804536 hasConcept C200170125 @default.
• W2038804536 hasConcept C24998067 @default.
• W2038804536 hasConcept C2777319143 @default.
• W2038804536 hasConcept C2778187257 @default.
• W2038804536 hasConcept C2778542668 @default.
• W2038804536 hasConcept C2779134260 @default.

• next