Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038804827> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2038804827 endingPage "629" @default.
- W2038804827 startingPage "619" @default.
- W2038804827 abstract "[5,6,8,9,11,12,14,15-3H8]-Thromboxane B2 was injected into the saphenous vein of female cynomolgus monkeys, and blood samples were withdrawn from the contralateral saphenous vein. The compound was eliminated from the circulation with a half-life of about 10 min after an initial rapid disappearance. Some more polar products appeared with time, and also small amounts of material less polar than thromboxane B2; however, the dominating compound in all blood samples was unconverted thromboxane B2. About 45% of the given dose of tritium was excreted into urine in 48 hrs. Several metabolites of thromboxane B2 were found. The major urinary metabolite was identified as dinorthromboxane B2 (about 32% of urinary radioactivity). Unconverted thromboxane B2 was also found in considerable amounts (13% of urinary radioactivity). It is concluded that 1) dehydrogenation at C-12 is not a major pathway in the degradation of this compound, in contrast to metabolism at the corresponding C-15 alcohol group of prostaglandins; 2) after having gained access to the circulation, thromboxane B2 is the main circulating compound; however, assay of thromboxane B2 in plasma will be complicated or precluded by large artifactual production of the compound by platelets during sample collection." @default.
- W2038804827 created "2016-06-24" @default.
- W2038804827 creator A5021414175 @default.
- W2038804827 date "1977-04-01" @default.
- W2038804827 modified "2023-10-07" @default.
- W2038804827 title "Metabolism of thromboxane B2 in the cynomolgus monkey" @default.
- W2038804827 cites W1497939987 @default.
- W2038804827 cites W1981749642 @default.
- W2038804827 cites W2031311321 @default.
- W2038804827 cites W2035879817 @default.
- W2038804827 cites W2057654689 @default.
- W2038804827 cites W2091448894 @default.
- W2038804827 cites W2093187211 @default.
- W2038804827 cites W2144446627 @default.
- W2038804827 cites W4241341214 @default.
- W2038804827 cites W4252477956 @default.
- W2038804827 doi "https://doi.org/10.1016/0090-6980(77)90233-7" @default.
- W2038804827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/404670" @default.
- W2038804827 hasPublicationYear "1977" @default.
- W2038804827 type Work @default.
- W2038804827 sameAs 2038804827 @default.
- W2038804827 citedByCount "47" @default.
- W2038804827 crossrefType "journal-article" @default.
- W2038804827 hasAuthorship W2038804827A5021414175 @default.
- W2038804827 hasConcept C126322002 @default.
- W2038804827 hasConcept C134018914 @default.
- W2038804827 hasConcept C185592680 @default.
- W2038804827 hasConcept C2776785769 @default.
- W2038804827 hasConcept C2777477808 @default.
- W2038804827 hasConcept C2780026642 @default.
- W2038804827 hasConcept C2781024287 @default.
- W2038804827 hasConcept C2781080829 @default.
- W2038804827 hasConcept C55493867 @default.
- W2038804827 hasConcept C62231903 @default.
- W2038804827 hasConcept C71924100 @default.
- W2038804827 hasConcept C77411442 @default.
- W2038804827 hasConcept C89560881 @default.
- W2038804827 hasConceptScore W2038804827C126322002 @default.
- W2038804827 hasConceptScore W2038804827C134018914 @default.
- W2038804827 hasConceptScore W2038804827C185592680 @default.
- W2038804827 hasConceptScore W2038804827C2776785769 @default.
- W2038804827 hasConceptScore W2038804827C2777477808 @default.
- W2038804827 hasConceptScore W2038804827C2780026642 @default.
- W2038804827 hasConceptScore W2038804827C2781024287 @default.
- W2038804827 hasConceptScore W2038804827C2781080829 @default.
- W2038804827 hasConceptScore W2038804827C55493867 @default.
- W2038804827 hasConceptScore W2038804827C62231903 @default.
- W2038804827 hasConceptScore W2038804827C71924100 @default.
- W2038804827 hasConceptScore W2038804827C77411442 @default.
- W2038804827 hasConceptScore W2038804827C89560881 @default.
- W2038804827 hasIssue "4" @default.
- W2038804827 hasLocation W20388048271 @default.
- W2038804827 hasLocation W20388048272 @default.
- W2038804827 hasOpenAccess W2038804827 @default.
- W2038804827 hasPrimaryLocation W20388048271 @default.
- W2038804827 hasRelatedWork W1964674100 @default.
- W2038804827 hasRelatedWork W2004608162 @default.
- W2038804827 hasRelatedWork W2044880765 @default.
- W2038804827 hasRelatedWork W2053182919 @default.
- W2038804827 hasRelatedWork W2077181129 @default.
- W2038804827 hasRelatedWork W2402671118 @default.
- W2038804827 hasRelatedWork W2470326181 @default.
- W2038804827 hasRelatedWork W2964124402 @default.
- W2038804827 hasRelatedWork W6811237 @default.
- W2038804827 hasRelatedWork W98406121 @default.
- W2038804827 hasVolume "13" @default.
- W2038804827 isParatext "false" @default.
- W2038804827 isRetracted "false" @default.
- W2038804827 magId "2038804827" @default.
- W2038804827 workType "article" @default.