FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038805557> ?p ?o ?g. }

• W2038805557 endingPage "e705" @default.
• W2038805557 startingPage "e705" @default.
• W2038805557 abstract "Risk factors associated with L. donovani visceral leishmaniasis (VL; kala azar) relapse are poorly characterized.We investigated patient characteristics and drug regimens associated with VL relapse using data from Médecins Sans Frontières - Holland (MSF) treatment centres in Southern Sudan. We used MSF operational data to investigate trends in VL relapse and associated risk factors.We obtained data for 8,800 primary VL and 621 relapse VL patients treated between 1999 and 2007. Records of previous treatment for 166 VL relapse patients (26.7%) were compared with 7,924 primary VL patients who had no record of subsequent relapse. Primary VL patients who relapsed had larger spleens on admission (Hackett grade >or=3 vs 0, odds ratio (OR) for relapse = 3.62 (95% CI 1.08, 12.12)) and on discharge (Hackett grade >or=3 vs 0, OR = 5.50 (1.84, 16.49)). Age, sex, malnutrition, mobility, and complications of treatment were not associated with risk of relapse, nor was there any trend over time. Treatment with 17-day sodium stibogluconate/paromomycin (SSG/PM) combination therapy vs 30-day SSG monotherapy was associated with increased risk of relapse (OR = 2.08 (1.21, 3.58)) but reduced risk of death (OR = 0.27 (0.20, 0.37)), although these estimates are likely to be residually confounded. MSF operational data showed a crude upward trend in the proportion of VL relapse patients (annual percentage change (APC) = 11.4% (-3.4%, 28.5%)) and a downward trend in deaths (APC = -18.1% (-22.5%, -13.4%)).Splenomegaly and 17-day SSG/PM vs 30-day SSG were associated with increased risk of VL relapse. The crude upward trend in VL relapses in Southern Sudan may be attributable to improved access to treatment and reduced mortality due to SSG/PM combination therapy." @default.
• W2038805557 created "2016-06-24" @default.
• W2038805557 creator A5031626110 @default.
• W2038805557 creator A5039156848 @default.
• W2038805557 creator A5040632164 @default.
• W2038805557 creator A5042884206 @default.
• W2038805557 creator A5055425360 @default.
• W2038805557 creator A5085293043 @default.
• W2038805557 creator A5091332937 @default.
• W2038805557 date "2010-06-08" @default.
• W2038805557 modified "2023-10-02" @default.
• W2038805557 title "Visceral Leishmaniasis Relapse in Southern Sudan (1999–2007): A Retrospective Study of Risk Factors and Trends" @default.
• W2038805557 cites W1595660422 @default.
• W2038805557 cites W1899376107 @default.
• W2038805557 cites W1971413150 @default.
• W2038805557 cites W1977383033 @default.
• W2038805557 cites W1984838539 @default.
• W2038805557 cites W2001692225 @default.
• W2038805557 cites W2004637228 @default.
• W2038805557 cites W2025134183 @default.
• W2038805557 cites W2036458856 @default.
• W2038805557 cites W2038565126 @default.
• W2038805557 cites W2052276776 @default.
• W2038805557 cites W2069247542 @default.
• W2038805557 cites W2077618811 @default.
• W2038805557 cites W2079451971 @default.
• W2038805557 cites W2119749072 @default.
• W2038805557 cites W2130955520 @default.
• W2038805557 cites W2137600992 @default.
• W2038805557 cites W2141644704 @default.
• W2038805557 cites W2142409861 @default.
• W2038805557 cites W2143657662 @default.
• W2038805557 cites W2146292123 @default.
• W2038805557 cites W2148924243 @default.
• W2038805557 cites W2151324264 @default.
• W2038805557 cites W2157865685 @default.
• W2038805557 cites W2170801146 @default.
• W2038805557 cites W4237895871 @default.
• W2038805557 doi "https://doi.org/10.1371/journal.pntd.0000705" @default.
• W2038805557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2882338" @default.
• W2038805557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20544032" @default.
• W2038805557 hasPublicationYear "2010" @default.
• W2038805557 type Work @default.
• W2038805557 sameAs 2038805557 @default.
• W2038805557 citedByCount "28" @default.
• W2038805557 countsByYear W20388055572012 @default.
• W2038805557 countsByYear W20388055572013 @default.
• W2038805557 countsByYear W20388055572014 @default.
• W2038805557 countsByYear W20388055572015 @default.
• W2038805557 countsByYear W20388055572016 @default.
• W2038805557 countsByYear W20388055572017 @default.
• W2038805557 countsByYear W20388055572018 @default.
• W2038805557 countsByYear W20388055572019 @default.
• W2038805557 countsByYear W20388055572020 @default.
• W2038805557 countsByYear W20388055572021 @default.
• W2038805557 countsByYear W20388055572022 @default.
• W2038805557 crossrefType "journal-article" @default.
• W2038805557 hasAuthorship W2038805557A5031626110 @default.
• W2038805557 hasAuthorship W2038805557A5039156848 @default.
• W2038805557 hasAuthorship W2038805557A5040632164 @default.
• W2038805557 hasAuthorship W2038805557A5042884206 @default.
• W2038805557 hasAuthorship W2038805557A5055425360 @default.
• W2038805557 hasAuthorship W2038805557A5085293043 @default.
• W2038805557 hasAuthorship W2038805557A5091332937 @default.
• W2038805557 hasBestOaLocation W20388055571 @default.
• W2038805557 hasConcept C126322002 @default.
• W2038805557 hasConcept C156957248 @default.
• W2038805557 hasConcept C167135981 @default.
• W2038805557 hasConcept C203014093 @default.
• W2038805557 hasConcept C2776114741 @default.
• W2038805557 hasConcept C2776555147 @default.
• W2038805557 hasConcept C2777787772 @default.
• W2038805557 hasConcept C2778689377 @default.
• W2038805557 hasConcept C2780122544 @default.
• W2038805557 hasConcept C501593827 @default.
• W2038805557 hasConcept C71924100 @default.
• W2038805557 hasConcept C86803240 @default.
• W2038805557 hasConcept C89423630 @default.
• W2038805557 hasConceptScore W2038805557C126322002 @default.
• W2038805557 hasConceptScore W2038805557C156957248 @default.
• W2038805557 hasConceptScore W2038805557C167135981 @default.
• W2038805557 hasConceptScore W2038805557C203014093 @default.
• W2038805557 hasConceptScore W2038805557C2776114741 @default.
• W2038805557 hasConceptScore W2038805557C2776555147 @default.
• W2038805557 hasConceptScore W2038805557C2777787772 @default.
• W2038805557 hasConceptScore W2038805557C2778689377 @default.
• W2038805557 hasConceptScore W2038805557C2780122544 @default.
• W2038805557 hasConceptScore W2038805557C501593827 @default.
• W2038805557 hasConceptScore W2038805557C71924100 @default.
• W2038805557 hasConceptScore W2038805557C86803240 @default.
• W2038805557 hasConceptScore W2038805557C89423630 @default.
• W2038805557 hasIssue "6" @default.
• W2038805557 hasLocation W20388055571 @default.
• W2038805557 hasLocation W20388055572 @default.
• W2038805557 hasLocation W20388055573 @default.
• W2038805557 hasLocation W20388055574 @default.
• W2038805557 hasOpenAccess W2038805557 @default.
• W2038805557 hasPrimaryLocation W20388055571 @default.

• next