FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038805797> ?p ?o ?g. }

• W2038805797 endingPage "228" @default.
• W2038805797 startingPage "220" @default.
• W2038805797 abstract "Epithelial barrier defects are well known in coeliac disease, but the mechanisms are only poorly defined. It is unclear, whether barrier disturbance reflects upregulated epithelial transcytosis or paracellular leakage.To characterise the molecular structure and function of the epithelial tight junction (TJ) and mechanisms of its dysregulation.Molecular analysis of proteins involved in TJ assembly and their regulation was performed by western blotting and confocal microscopy correlated to electrophysiology.A complex alteration of the composition of epithelial TJ proteins (with more pore-forming claudins like claudin-2 and a reduction in tightening claudins like claudin-3, -5 and -7) was found for protein expression and subcellular localisation, responsible for an increase in paracellular biotin-NHS uptake. In contrast, epithelial apoptosis was only moderately elevated (accounting for a minor portion of barrier defects) and epithelial gross lesions--for example, at cell extrusion zones, were absent. This TJ alteration was linked to an altered localisation/expression of proteins regulating TJ assembly, the polarity complex protein Par-3 and the serine-/threonine phosphatase PP-1.Changes in cell polarity proteins Par-3 and PP-1 are associated with altered expression and assembly of TJ proteins claudin-2, -3, -5 and -7 and ZO-1, causing paracellular leakage in active coeliac disease." @default.
• W2038805797 created "2016-06-24" @default.
• W2038805797 creator A5016824027 @default.
• W2038805797 creator A5018914500 @default.
• W2038805797 creator A5022991035 @default.
• W2038805797 creator A5023836558 @default.
• W2038805797 creator A5031972677 @default.
• W2038805797 creator A5037631121 @default.
• W2038805797 creator A5040194271 @default.
• W2038805797 creator A5042079514 @default.
• W2038805797 creator A5046961936 @default.
• W2038805797 creator A5055607557 @default.
• W2038805797 creator A5059537461 @default.
• W2038805797 creator A5076625619 @default.
• W2038805797 creator A5081013332 @default.
• W2038805797 creator A5089930328 @default.
• W2038805797 date "2011-08-24" @default.
• W2038805797 modified "2023-10-10" @default.
• W2038805797 title "Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease" @default.
• W2038805797 cites W1970554839 @default.
• W2038805797 cites W1971109432 @default.
• W2038805797 cites W1973152745 @default.
• W2038805797 cites W1976226144 @default.
• W2038805797 cites W1987896801 @default.
• W2038805797 cites W1988528086 @default.
• W2038805797 cites W1989506542 @default.
• W2038805797 cites W1991346408 @default.
• W2038805797 cites W1992369970 @default.
• W2038805797 cites W1994349104 @default.
• W2038805797 cites W2024005495 @default.
• W2038805797 cites W2027235566 @default.
• W2038805797 cites W2031904940 @default.
• W2038805797 cites W2040376369 @default.
• W2038805797 cites W2040997638 @default.
• W2038805797 cites W2057924283 @default.
• W2038805797 cites W2059356721 @default.
• W2038805797 cites W2060142607 @default.
• W2038805797 cites W2064281440 @default.
• W2038805797 cites W2069466944 @default.
• W2038805797 cites W2075468859 @default.
• W2038805797 cites W2081599491 @default.
• W2038805797 cites W2081951192 @default.
• W2038805797 cites W2083465992 @default.
• W2038805797 cites W2091000930 @default.
• W2038805797 cites W2103536507 @default.
• W2038805797 cites W2104567497 @default.
• W2038805797 cites W2110174748 @default.
• W2038805797 cites W2113971980 @default.
• W2038805797 cites W2114868173 @default.
• W2038805797 cites W2120914031 @default.
• W2038805797 cites W2123230988 @default.
• W2038805797 cites W2131204388 @default.
• W2038805797 cites W2138925273 @default.
• W2038805797 cites W2140551998 @default.
• W2038805797 cites W2141060099 @default.
• W2038805797 cites W2148090028 @default.
• W2038805797 cites W2149199388 @default.
• W2038805797 cites W2149831912 @default.
• W2038805797 cites W2150771988 @default.
• W2038805797 cites W2154607802 @default.
• W2038805797 cites W2159980792 @default.
• W2038805797 cites W2161266638 @default.
• W2038805797 cites W2162062989 @default.
• W2038805797 cites W2166710590 @default.
• W2038805797 cites W2168436318 @default.
• W2038805797 cites W74167591 @default.
• W2038805797 doi "https://doi.org/10.1136/gutjnl-2011-300123" @default.
• W2038805797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21865402" @default.
• W2038805797 hasPublicationYear "2011" @default.
• W2038805797 type Work @default.
• W2038805797 sameAs 2038805797 @default.
• W2038805797 citedByCount "103" @default.
• W2038805797 countsByYear W20388057972012 @default.
• W2038805797 countsByYear W20388057972013 @default.
• W2038805797 countsByYear W20388057972014 @default.
• W2038805797 countsByYear W20388057972015 @default.
• W2038805797 countsByYear W20388057972016 @default.
• W2038805797 countsByYear W20388057972017 @default.
• W2038805797 countsByYear W20388057972018 @default.
• W2038805797 countsByYear W20388057972019 @default.
• W2038805797 countsByYear W20388057972020 @default.
• W2038805797 countsByYear W20388057972021 @default.
• W2038805797 countsByYear W20388057972022 @default.
• W2038805797 countsByYear W20388057972023 @default.
• W2038805797 crossrefType "journal-article" @default.
• W2038805797 hasAuthorship W2038805797A5016824027 @default.
• W2038805797 hasAuthorship W2038805797A5018914500 @default.
• W2038805797 hasAuthorship W2038805797A5022991035 @default.
• W2038805797 hasAuthorship W2038805797A5023836558 @default.
• W2038805797 hasAuthorship W2038805797A5031972677 @default.
• W2038805797 hasAuthorship W2038805797A5037631121 @default.
• W2038805797 hasAuthorship W2038805797A5040194271 @default.
• W2038805797 hasAuthorship W2038805797A5042079514 @default.
• W2038805797 hasAuthorship W2038805797A5046961936 @default.
• W2038805797 hasAuthorship W2038805797A5055607557 @default.
• W2038805797 hasAuthorship W2038805797A5059537461 @default.
• W2038805797 hasAuthorship W2038805797A5076625619 @default.
• W2038805797 hasAuthorship W2038805797A5081013332 @default.

• next