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• W2038808393 abstract "1 High-threshold Ca2+ channel currents were measured every 15 s following a 200 ms voltage step from −80 mV to 0 mV in order to study the coupling mechanism between neurotransmitter receptors and Ca2+ channels in neurones acutely isolated from the nucleus tractus solitarius (NTS) of the rat. 2 Application of 30 μm baclofen (GABAB receptor agonist) caused 38.9 ± 1.2% inhibition of the peak inward Ba2+ current (IBa2+) in most NTS cells tested (n = 85 of 88). Somatostatin, 300 nM, also reduced IBa2+ by 31.3 ± 1.6% in 53 cells of 82 tested. 3 Activation of μ-opioid-, GABAB- or somatostatin-receptors inhibited both N- and P/Q-type Ca2+ channels. 4 The inhibition of Ca2+ currents by DAMGO (μ-opioid receptor agonist), baclofen and somatostatin was reduced by treatment with pertussis toxin and partially relieved by application of a 50 ms conditioning prepulse to +80 mV. This suggests that a pertussis toxin-sensitive G-protein was involved in the neurotransmitter-mediated action in the observed inhibition of Ca2+ currents. 5 Intracellular loading with an antiserum raised against the amino terminus of Goα (GC/2) markedly attenuated the somatostatin-induced inhibition, but did not block the DAMGO- and baclofen-induced inhibition. 6 These findings suggest at least two different pertussis toxin-sensitive G-protein-mediated pathways are involved in receptor-induced inhibition of Ca2+ currents in the NTS." @default.
• W2038808393 created "2016-06-24" @default.
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• W2038808393 date "1996-07-01" @default.
• W2038808393 modified "2023-10-16" @default.
• W2038808393 title "Mechanism of inhibition of calcium channels in rat nucleus tractus solitarius by neurotransmitters" @default.
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• W2038808393 doi "https://doi.org/10.1111/j.1476-5381.1996.tb15543.x" @default.
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