FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038824695> ?p ?o ?g. }

• W2038824695 endingPage "R208" @default.
• W2038824695 startingPage "R208" @default.
• W2038824695 abstract "Smoking increases the risk of developing rheumatoid arthritis (RA) and affects the severity of established RA. Smoking can impact on Th17 lymphocyte differentiation and function through activation of the aryl hydrocarbon receptor (AHR), a process with implications for the pathogenic mechanisms in RA that involve the cytokine, interleukin (IL)-17A. The objective of this study was to establish any effect of smoking on the inflammatory tissue lesions of rheumatoid arthritis via the AHR and IL-17A. Twenty synovial and eighteen subcutaneous nodule tissue samples from 31 patients with RA were studied. Patient smoking status at the time of tissue collection was established. Expression of AHR, CYP1A1, AHRR, IL6, IL17A, IL17F, IL22, IL23, IL23R, IFNG, TBX21, IDO1 and FOXP3 genes were assessed in tissues and cultured cells using real-time PCR. Two-colour immunofluorescence was used to co-localise AHR and CYP1A1 protein in synovial tissues. The response of monocytes and monocyte-derived dendritic cells (mo-DCs) to the AHR agonist, benzo(a)pyrene (BaP) was compared in vitro. AHR gene expression was demonstrated in rheumatoid synovial tissues and nodules with significantly greater expression in synovia. Expression was not influenced by smoking in either tissue. Evidence of AHR activation, indicated by CYP1A1 and AHRR gene expression, was found only in synovia from patients who smoked. However, IL17A gene expression was lower in synovia from smokers. TBX21 and FOXP3 expression was not affected by smoking. Within the synovial tissues of smokers the principal cell type with evidence of AHR activation was a subset of synovial DCs. This observation was consistent with the sensitivity of human mo-DCs to BaP stimulation demonstrated in vitro. Exposure to BaP affected mo-DC function as demonstrated by decreased IL6 expression induced by PolyI:C, without affecting indoleamine 2,3 dioxygenase (IDO)1 expression. Our findings show that one effect of smoking on inflamed rheumatoid synovial tissue involves activation of the AHR pathway. A subset of synovial DCs is important in the response to cigarette smoke. The potential for smoking to affect DC behaviour in joint tissues has relevance to both early and late phases of RA pathogenesis and warrants further investigation." @default.
• W2038824695 created "2016-06-24" @default.
• W2038824695 creator A5013215899 @default.
• W2038824695 creator A5039071848 @default.
• W2038824695 creator A5058941145 @default.
• W2038824695 creator A5061552694 @default.
• W2038824695 date "2012-01-01" @default.
• W2038824695 modified "2023-10-06" @default.
• W2038824695 title "Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis" @default.
• W2038824695 cites W1603640418 @default.
• W2038824695 cites W1988157050 @default.
• W2038824695 cites W1992751771 @default.
• W2038824695 cites W1993003564 @default.
• W2038824695 cites W2001857046 @default.
• W2038824695 cites W2002396362 @default.
• W2038824695 cites W2005405421 @default.
• W2038824695 cites W2014830732 @default.
• W2038824695 cites W2017893786 @default.
• W2038824695 cites W2020427416 @default.
• W2038824695 cites W2033366171 @default.
• W2038824695 cites W2052047947 @default.
• W2038824695 cites W2063811338 @default.
• W2038824695 cites W2068912461 @default.
• W2038824695 cites W2080988284 @default.
• W2038824695 cites W2083721707 @default.
• W2038824695 cites W2088718071 @default.
• W2038824695 cites W2093120748 @default.
• W2038824695 cites W2094231073 @default.
• W2038824695 cites W2103089222 @default.
• W2038824695 cites W2107312924 @default.
• W2038824695 cites W2107560119 @default.
• W2038824695 cites W2109955020 @default.
• W2038824695 cites W2119716615 @default.
• W2038824695 cites W2130420229 @default.
• W2038824695 cites W2130631271 @default.
• W2038824695 cites W2131872753 @default.
• W2038824695 cites W2132147591 @default.
• W2038824695 cites W2136131602 @default.
• W2038824695 cites W2136748436 @default.
• W2038824695 cites W2141655217 @default.
• W2038824695 cites W2142219725 @default.
• W2038824695 cites W2152348310 @default.
• W2038824695 cites W2162276444 @default.
• W2038824695 cites W2162370269 @default.
• W2038824695 cites W2165431421 @default.
• W2038824695 cites W4210968471 @default.
• W2038824695 doi "https://doi.org/10.1186/ar4046" @default.
• W2038824695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3580520" @default.
• W2038824695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23036591" @default.
• W2038824695 hasPublicationYear "2012" @default.
• W2038824695 type Work @default.
• W2038824695 sameAs 2038824695 @default.
• W2038824695 citedByCount "45" @default.
• W2038824695 countsByYear W20388246952013 @default.
• W2038824695 countsByYear W20388246952014 @default.
• W2038824695 countsByYear W20388246952015 @default.
• W2038824695 countsByYear W20388246952017 @default.
• W2038824695 countsByYear W20388246952018 @default.
• W2038824695 countsByYear W20388246952019 @default.
• W2038824695 countsByYear W20388246952020 @default.
• W2038824695 countsByYear W20388246952021 @default.
• W2038824695 countsByYear W20388246952022 @default.
• W2038824695 countsByYear W20388246952023 @default.
• W2038824695 crossrefType "journal-article" @default.
• W2038824695 hasAuthorship W2038824695A5013215899 @default.
• W2038824695 hasAuthorship W2038824695A5039071848 @default.
• W2038824695 hasAuthorship W2038824695A5058941145 @default.
• W2038824695 hasAuthorship W2038824695A5061552694 @default.
• W2038824695 hasBestOaLocation W20388246951 @default.
• W2038824695 hasConcept C104317684 @default.
• W2038824695 hasConcept C142724271 @default.
• W2038824695 hasConcept C203014093 @default.
• W2038824695 hasConcept C2776914184 @default.
• W2038824695 hasConcept C2777575956 @default.
• W2038824695 hasConcept C2777652487 @default.
• W2038824695 hasConcept C2778690821 @default.
• W2038824695 hasConcept C2779727006 @default.
• W2038824695 hasConcept C33594762 @default.
• W2038824695 hasConcept C47348012 @default.
• W2038824695 hasConcept C50345908 @default.
• W2038824695 hasConcept C55493867 @default.
• W2038824695 hasConcept C71924100 @default.
• W2038824695 hasConcept C74172505 @default.
• W2038824695 hasConcept C86339819 @default.
• W2038824695 hasConcept C86803240 @default.
• W2038824695 hasConcept C8891405 @default.
• W2038824695 hasConceptScore W2038824695C104317684 @default.
• W2038824695 hasConceptScore W2038824695C142724271 @default.
• W2038824695 hasConceptScore W2038824695C203014093 @default.
• W2038824695 hasConceptScore W2038824695C2776914184 @default.
• W2038824695 hasConceptScore W2038824695C2777575956 @default.
• W2038824695 hasConceptScore W2038824695C2777652487 @default.
• W2038824695 hasConceptScore W2038824695C2778690821 @default.
• W2038824695 hasConceptScore W2038824695C2779727006 @default.
• W2038824695 hasConceptScore W2038824695C33594762 @default.
• W2038824695 hasConceptScore W2038824695C47348012 @default.
• W2038824695 hasConceptScore W2038824695C50345908 @default.
• W2038824695 hasConceptScore W2038824695C55493867 @default.

• next