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- W2038832337 endingPage "70" @default.
- W2038832337 startingPage "149" @default.
- W2038832337 abstract "The Epstein-Barr virus (EBV) is a herpes virus which establishes a life-long persistent infection in over 90% of the human adult population world-wide. Based on its association with a variety of lymphoid and epithelial malignancies, EBV has been classified as a group 1 carcinogen by the International Agency for Research on Cancer. In this article we discuss the evidence supporting an aetiological role for EBV in the pathogenesis of human tumours. The biology of EBV infection will be described with special emphasis on viral transforming gene products. A brief survey of EBV-associated tumours is followed by a discussion of specific problems. Evidence is presented which suggests that failures of the EBV-specific immunity may play a role in the pathogenesis of EBV-associated tumours also in patients without clinically manifest immunodeficiencies. Finally, the timing of EBV infection in the pathogenesis of virus-associated malignancies is discussed. There is good evidence that EBV infection precedes expansion of the malignant cell populations in some virus-associated tumours. However, this is clearly not always the case and for some of these tumours there are indications that clonal genetic alterations may occur prior to EBV infection. Thus, whilst there is good evidence to suggest that EBV is a human carcinogen, its precise role(s) in the development of virus-associated human tumours requires clarification." @default.
- W2038832337 created "2016-06-24" @default.
- W2038832337 creator A5012470161 @default.
- W2038832337 creator A5036094965 @default.
- W2038832337 creator A5052569462 @default.
- W2038832337 date "2001-06-01" @default.
- W2038832337 modified "2023-10-17" @default.
- W2038832337 title "Epstein-Barr virus infection and human malignancies." @default.
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