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• W2038838016 abstract "There is considerable interest in muscarinic acetylcholine receptor (mAChR) subtype selective agents as cholinomimetics for the treatment of senile dementia of the Alzheimer's type (SDAT). A series of substituted analogs similar to the muscarinic agonists UH5 and UH28 (analogs of the muscarinic agonist oxotremorine) were synthesized and evaluated pharmacologically. Several oxime analogues of UH5 demonstrate agonist-like properties in vitro at muscarinic receptors. One oxime in this series (Compound 18) was found to be almost five fold more m1 selective than UH5." @default.
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• W2038838016 date "1992-08-01" @default.
• W2038838016 modified "2023-10-04" @default.
• W2038838016 title "Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5" @default.
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• W2038838016 doi "https://doi.org/10.1016/s0960-894x(00)80535-1" @default.
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