FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038838233> ?p ?o ?g. }

• W2038838233 endingPage "e30311" @default.
• W2038838233 startingPage "e30311" @default.
• W2038838233 abstract "Background Programmed cell death 4 (PDCD4), originally identified as the neoplastic transformation inhibitor, was attenuated in various cancer types. Our previous study demonstrated a continuous down-regulation of PDCD4 expression in the sequence of normal-borderline-malignant ovarian tissue samples and a significant correlation of PDCD4 expression with disease-free survival. The objective of the current study was to further investigate the function and modulation of PDCD4 in ovarian cancer cells. Principal Findings We demonstrated that ectopic PDCD4 expression significantly inhibited cell proliferation by inducing cell cycle arrest at G1 stage and up-regulation of cell cycle inhibitors of p27 and p21. Cell migration and invasion were also inhibited by PDCD4. PDCD4 over-expressing cells exhibited elevated phosphatase and tensin homolog (PTEN) and inhibited protein kinase B (p-Akt). In addition, the expression of PDCD4 was up-regulated and it was exported to the cytoplasm upon serum withdrawal treatment, but it was rapidly depleted via proteasomal degradation upon serum re-administration. Treatment of a phosphoinositide 3-kinase (PI3K) inhibitor prevented the degradation of PDCD4, indicating the involvement of PI3K-Akt pathway in the modulation of PDCD4. Conclusion PDCD4 may play a critical function in arresting cell cycle progression at key checkpoint, thus inhibiting cell proliferation, as well as suppressing tumour metastasis. The PI3K-Akt pathway was implied to be involved in the regulation of PDCD4 degradation in ovarian cancer cells. In response to the stress condition, endogenous PDCD4 was able to shuttle between cell compartments to perform its diverted functions." @default.
• W2038838233 created "2016-06-24" @default.
• W2038838233 creator A5012872644 @default.
• W2038838233 creator A5040172079 @default.
• W2038838233 creator A5066245492 @default.
• W2038838233 creator A5072373948 @default.
• W2038838233 date "2012-01-17" @default.
• W2038838233 modified "2023-10-18" @default.
• W2038838233 title "Tumour Suppressive Function and Modulation of Programmed Cell Death 4 (PDCD4) in Ovarian Cancer" @default.
• W2038838233 cites W1965598882 @default.
• W2038838233 cites W1966417898 @default.
• W2038838233 cites W1970111367 @default.
• W2038838233 cites W1981747282 @default.
• W2038838233 cites W1984490528 @default.
• W2038838233 cites W1986424797 @default.
• W2038838233 cites W1998639716 @default.
• W2038838233 cites W2027696262 @default.
• W2038838233 cites W2038246587 @default.
• W2038838233 cites W2041809988 @default.
• W2038838233 cites W2042812307 @default.
• W2038838233 cites W2044591093 @default.
• W2038838233 cites W2047227271 @default.
• W2038838233 cites W2055897952 @default.
• W2038838233 cites W2067617459 @default.
• W2038838233 cites W2070300401 @default.
• W2038838233 cites W2071878775 @default.
• W2038838233 cites W2081476178 @default.
• W2038838233 cites W2098263598 @default.
• W2038838233 cites W2104052951 @default.
• W2038838233 cites W2106333239 @default.
• W2038838233 cites W2118054479 @default.
• W2038838233 cites W2131687108 @default.
• W2038838233 cites W2131941047 @default.
• W2038838233 cites W2149193228 @default.
• W2038838233 cites W2151886488 @default.
• W2038838233 cites W2159430811 @default.
• W2038838233 cites W2165371985 @default.
• W2038838233 cites W2169289060 @default.
• W2038838233 cites W2169301624 @default.
• W2038838233 cites W2257484201 @default.
• W2038838233 doi "https://doi.org/10.1371/journal.pone.0030311" @default.
• W2038838233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3260274" @default.
• W2038838233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22272332" @default.
• W2038838233 hasPublicationYear "2012" @default.
• W2038838233 type Work @default.
• W2038838233 sameAs 2038838233 @default.
• W2038838233 citedByCount "55" @default.
• W2038838233 countsByYear W20388382332012 @default.
• W2038838233 countsByYear W20388382332013 @default.
• W2038838233 countsByYear W20388382332014 @default.
• W2038838233 countsByYear W20388382332015 @default.
• W2038838233 countsByYear W20388382332016 @default.
• W2038838233 countsByYear W20388382332017 @default.
• W2038838233 countsByYear W20388382332018 @default.
• W2038838233 countsByYear W20388382332019 @default.
• W2038838233 countsByYear W20388382332020 @default.
• W2038838233 countsByYear W20388382332021 @default.
• W2038838233 countsByYear W20388382332022 @default.
• W2038838233 crossrefType "journal-article" @default.
• W2038838233 hasAuthorship W2038838233A5012872644 @default.
• W2038838233 hasAuthorship W2038838233A5040172079 @default.
• W2038838233 hasAuthorship W2038838233A5066245492 @default.
• W2038838233 hasAuthorship W2038838233A5072373948 @default.
• W2038838233 hasBestOaLocation W20388382331 @default.
• W2038838233 hasConcept C121608353 @default.
• W2038838233 hasConcept C1491633281 @default.
• W2038838233 hasConcept C190283241 @default.
• W2038838233 hasConcept C2777609662 @default.
• W2038838233 hasConcept C2779549131 @default.
• W2038838233 hasConcept C2780427987 @default.
• W2038838233 hasConcept C29537977 @default.
• W2038838233 hasConcept C31573885 @default.
• W2038838233 hasConcept C502942594 @default.
• W2038838233 hasConcept C54355233 @default.
• W2038838233 hasConcept C55493867 @default.
• W2038838233 hasConcept C62112901 @default.
• W2038838233 hasConcept C62478195 @default.
• W2038838233 hasConcept C75217442 @default.
• W2038838233 hasConcept C81885089 @default.
• W2038838233 hasConcept C86554907 @default.
• W2038838233 hasConcept C86803240 @default.
• W2038838233 hasConcept C95444343 @default.
• W2038838233 hasConcept C96232424 @default.
• W2038838233 hasConcept C97037327 @default.
• W2038838233 hasConceptScore W2038838233C121608353 @default.
• W2038838233 hasConceptScore W2038838233C1491633281 @default.
• W2038838233 hasConceptScore W2038838233C190283241 @default.
• W2038838233 hasConceptScore W2038838233C2777609662 @default.
• W2038838233 hasConceptScore W2038838233C2779549131 @default.
• W2038838233 hasConceptScore W2038838233C2780427987 @default.
• W2038838233 hasConceptScore W2038838233C29537977 @default.
• W2038838233 hasConceptScore W2038838233C31573885 @default.
• W2038838233 hasConceptScore W2038838233C502942594 @default.
• W2038838233 hasConceptScore W2038838233C54355233 @default.
• W2038838233 hasConceptScore W2038838233C55493867 @default.
• W2038838233 hasConceptScore W2038838233C62112901 @default.
• W2038838233 hasConceptScore W2038838233C62478195 @default.
• W2038838233 hasConceptScore W2038838233C75217442 @default.

• next