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- W2038852042 abstract "Abstract— In vitro photodynamic treatment of YAC-1 murine T-lymphoma cells with the hematoporphyrin derivative Photosan 3 and red light resulted in dose-dependent phototoxicity. Photodynamic pretreatment, however, did not render these cells more susceptible to macrophage-me-diated tumor cytotoxicity or the cytotoxic effects of mac-rophage-derived antitumor mediators like tumor necrosis factor aL (TNF-aL) or interferon bT (IFN-bT). Independent of the degree of photosensitization used, the cytotoxicity values obtained with macrophages or the different mediators were shifted by the respective values for phototoxicity, suggesting these effects to be additive and thus not interdependent. These data show that while higher overall tumor cytotoxicity can be achieved by a combination of photodynamic treatment and macro-phage-mediated tumor destruction, this apparently is not a result of enhanced sensitivity of photodynamically treated tumor cells to macrophage antitumor mechanisms in general" @default.
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- W2038852042 date "1997-09-01" @default.
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- W2038852042 title "Effect of Photodynamic Pretreatment on the Susceptibility of Murine Tumor Cells To Macrophage Antitumor Mechanisms" @default.
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- W2038852042 doi "https://doi.org/10.1111/j.1751-1097.1997.tb03162.x" @default.
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