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- W2038852811 abstract "The aim of the present study was to probe the structural integrity of insulin after being entrapped into chitosan/alginate nanoparticles produced by ionotropic polyelectrolyte pre-gelation. By manipulating the alginate:chitosan mass ratio and the pH during nanoparticle production, desired nanoparticles with a mean size of 850 (±88) nm and insulin association efficiency of 81 (±2)% were obtained. Insulin secondary structure was assessed by Fourier transform infrared (FTIR) and circular dichroism (CD) after entrapment into nanoparticles and after release from the particles under gastrointestinal simulated conditions. FTIR second-derivative spectra and area-overlap compared to an insulin standard confirmed that no significant conformational changes of insulin occurred in terms of α-helix and β-sheet content. Far-UV-CD spectra corroborated the preservation of insulin structure during the nanoparticle production procedure. The presented nanoparticulate system is a promising carrier for insulin oral delivery since it preserves insulin structure and therefore also, potentially, its bioactivity." @default.
- W2038852811 created "2016-06-24" @default.
- W2038852811 creator A5000425357 @default.
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- W2038852811 date "2007-01-01" @default.
- W2038852811 modified "2023-10-18" @default.
- W2038852811 title "Probing insulin’s secondary structure after entrapment into alginate/chitosan nanoparticles" @default.
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- W2038852811 doi "https://doi.org/10.1016/j.ejpb.2006.09.005" @default.
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