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- W2038858598 abstract "Antibodies are the fastest-growing segment of the biologics market. The success of antibody-based drugs resides in their exquisite specificity, high potency, stability, solubility, safety, and relatively inexpensive manufacturing process in comparison with other biologics. We outline here the structural studies and fundamental principles that define how antibodies interact with diverse targets. We also describe the antibody repertoires and affinity maturation mechanisms of humans, mice, and chickens, plus the use of novel single-domain antibodies in camelids and sharks. These species all utilize diverse evolutionary solutions to generate specific and high affinity antibodies and illustrate the plasticity of natural antibody repertoires. In addition, we discuss the multiple variations of man-made antibody repertoires designed and validated in the last two decades, which have served as tools to explore how the size, diversity, and composition of a repertoire impact the antibody discovery process." @default.
- W2038858598 created "2016-06-24" @default.
- W2038858598 creator A5042763414 @default.
- W2038858598 creator A5062343327 @default.
- W2038858598 date "2012-01-01" @default.
- W2038858598 modified "2023-09-28" @default.
- W2038858598 title "Natural and man-made V-gene repertoires for antibody discovery" @default.
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