Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038861306> ?p ?o ?g. }
- W2038861306 endingPage "637" @default.
- W2038861306 startingPage "632" @default.
- W2038861306 abstract "The potential initiating activity of diethylnitrosamine (DEN) was studied in a rapid production model for pancreatic carcinogenesis in hamsters developed in our laboratory incorporating the principle of selection based on resistance to cytotoxicity, originally demonstrated for liver carcinogenesis in rats. Female Syrian golden hamsters were given DEN at a dose of 100 mg/kg body weight or N-nitrosobis-(2-oxopropyI)amine (BOP) at a dose of 70 mg/kg body weight as initiators followed by 3 cycles of augmentation pressure (choline-deficient diet combined with DL-ethionine, L-methionine upon return to basal diet and then administration of 20 mg/kg body weight BOP), and killed 10 weeks after the beginning of the experiment. DEN followed by the augmentation pressure induced a 65% incidence of total pancreatic lesions including 15% carcinomas, while BOP followed by the augmentation pressure induced 100% incidence of total pancreatic lesions and 84.2% for carcinomas. These yields were significantly greater than those observed for augmentation pressure alone. The results thus indicate that DEN possesses weak initiating activity for pancreatic carcinogenesis under the present experimental conditions." @default.
- W2038861306 created "2016-06-24" @default.
- W2038861306 creator A5001170131 @default.
- W2038861306 creator A5004506343 @default.
- W2038861306 creator A5021720255 @default.
- W2038861306 creator A5023306924 @default.
- W2038861306 creator A5053510757 @default.
- W2038861306 creator A5058895525 @default.
- W2038861306 creator A5065375856 @default.
- W2038861306 creator A5072873559 @default.
- W2038861306 creator A5088612923 @default.
- W2038861306 date "1991-06-01" @default.
- W2038861306 modified "2023-10-02" @default.
- W2038861306 title "Initiating Activity of Diethylnitrosamine in a Rapid Production Model for Pancreatic Carcinomas in Syrian Hamsters" @default.
- W2038861306 cites W1484052432 @default.
- W2038861306 cites W1852847022 @default.
- W2038861306 cites W1902704469 @default.
- W2038861306 cites W1973690843 @default.
- W2038861306 cites W1974789605 @default.
- W2038861306 cites W2005381573 @default.
- W2038861306 cites W2029777732 @default.
- W2038861306 cites W2033019432 @default.
- W2038861306 cites W2055100270 @default.
- W2038861306 cites W2070256254 @default.
- W2038861306 cites W2082114741 @default.
- W2038861306 cites W2083163456 @default.
- W2038861306 cites W2086109625 @default.
- W2038861306 cites W2098376141 @default.
- W2038861306 cites W2119926459 @default.
- W2038861306 cites W2404421058 @default.
- W2038861306 cites W2463301805 @default.
- W2038861306 cites W41601273 @default.
- W2038861306 cites W4243988873 @default.
- W2038861306 doi "https://doi.org/10.1111/j.1349-7006.1991.tb01897.x" @default.
- W2038861306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5918498" @default.
- W2038861306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1649810" @default.
- W2038861306 hasPublicationYear "1991" @default.
- W2038861306 type Work @default.
- W2038861306 sameAs 2038861306 @default.
- W2038861306 citedByCount "6" @default.
- W2038861306 crossrefType "journal-article" @default.
- W2038861306 hasAuthorship W2038861306A5001170131 @default.
- W2038861306 hasAuthorship W2038861306A5004506343 @default.
- W2038861306 hasAuthorship W2038861306A5021720255 @default.
- W2038861306 hasAuthorship W2038861306A5023306924 @default.
- W2038861306 hasAuthorship W2038861306A5053510757 @default.
- W2038861306 hasAuthorship W2038861306A5058895525 @default.
- W2038861306 hasAuthorship W2038861306A5065375856 @default.
- W2038861306 hasAuthorship W2038861306A5072873559 @default.
- W2038861306 hasAuthorship W2038861306A5088612923 @default.
- W2038861306 hasBestOaLocation W20388613061 @default.
- W2038861306 hasConcept C114246631 @default.
- W2038861306 hasConcept C121608353 @default.
- W2038861306 hasConcept C126322002 @default.
- W2038861306 hasConcept C134018914 @default.
- W2038861306 hasConcept C147583825 @default.
- W2038861306 hasConcept C185592680 @default.
- W2038861306 hasConcept C2777395278 @default.
- W2038861306 hasConcept C2778024521 @default.
- W2038861306 hasConcept C2778575167 @default.
- W2038861306 hasConcept C2778764654 @default.
- W2038861306 hasConcept C2779306644 @default.
- W2038861306 hasConcept C2780486903 @default.
- W2038861306 hasConcept C2780912031 @default.
- W2038861306 hasConcept C2781123555 @default.
- W2038861306 hasConcept C515207424 @default.
- W2038861306 hasConcept C55493867 @default.
- W2038861306 hasConcept C555283112 @default.
- W2038861306 hasConcept C71924100 @default.
- W2038861306 hasConceptScore W2038861306C114246631 @default.
- W2038861306 hasConceptScore W2038861306C121608353 @default.
- W2038861306 hasConceptScore W2038861306C126322002 @default.
- W2038861306 hasConceptScore W2038861306C134018914 @default.
- W2038861306 hasConceptScore W2038861306C147583825 @default.
- W2038861306 hasConceptScore W2038861306C185592680 @default.
- W2038861306 hasConceptScore W2038861306C2777395278 @default.
- W2038861306 hasConceptScore W2038861306C2778024521 @default.
- W2038861306 hasConceptScore W2038861306C2778575167 @default.
- W2038861306 hasConceptScore W2038861306C2778764654 @default.
- W2038861306 hasConceptScore W2038861306C2779306644 @default.
- W2038861306 hasConceptScore W2038861306C2780486903 @default.
- W2038861306 hasConceptScore W2038861306C2780912031 @default.
- W2038861306 hasConceptScore W2038861306C2781123555 @default.
- W2038861306 hasConceptScore W2038861306C515207424 @default.
- W2038861306 hasConceptScore W2038861306C55493867 @default.
- W2038861306 hasConceptScore W2038861306C555283112 @default.
- W2038861306 hasConceptScore W2038861306C71924100 @default.
- W2038861306 hasIssue "6" @default.
- W2038861306 hasLocation W20388613061 @default.
- W2038861306 hasLocation W20388613062 @default.
- W2038861306 hasLocation W20388613063 @default.
- W2038861306 hasLocation W20388613064 @default.
- W2038861306 hasOpenAccess W2038861306 @default.
- W2038861306 hasPrimaryLocation W20388613061 @default.
- W2038861306 hasRelatedWork W1494806716 @default.
- W2038861306 hasRelatedWork W1983765718 @default.
- W2038861306 hasRelatedWork W1986939346 @default.
- W2038861306 hasRelatedWork W2012792036 @default.