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- W2038861845 abstract "Abstract Heterozygous disruption of the Men1 gene predisposes mice to the development of multiple endocrine tumors, accurately mimicking the human MEN1 cancer predisposition syndrome. Additionally, Men1 +/– mice frequently develop sex cord adenomas. The mechanism underlying the susceptibility of these mice to sex cord tumor development has not been fully determined, but data suggest it may involve transcriptional regulation of key growth promoting/repressing genes. To identify potential menin‐regulated genes that may be important for tumor suppression in sex cord cells, we compared the global gene expression profiles of testis and ovary adenomas with other endocrine tumors of the pancreas and pituitary from Men1 heterozygous mice and with control tissues. Gonadal tumors clustered separately from pancreas and pituitary tumors with only a few genes ( e.g., Cdkn2c ) commonly dysregulated in all tumor types. Testis and ovary tumors displayed a higher level of transcriptional similarity to each other than they did to their respective control tissues. Among genes that had decreased expression in tumors was significant over‐representation of genes associated with the TGF‐β, hedgehog and Wnt signaling, indicating that loss of menin function affects these pathways at the level of transcription. Aberrant protein expression in Leydig and granulosa cells of 2 transcriptionally dysregulated gene products, Gata6 and Csf1r were confirmed by immunohistochemistry. We propose that sex cord tumor susceptibility in Men1 +/– mice involves deregulated cell proliferation due to dysregulation of multiple cell growth regulating genes including: reduced Cdkn2c transcription, loss of TGF‐β pathway tumor suppressor function ( e.g., Gata6 ) and transcriptional activation of Csf1r. © 2008 Wiley‐Liss, Inc." @default.
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- W2038861845 date "2008-12-04" @default.
- W2038861845 modified "2023-10-15" @default.
- W2038861845 title "Global expression profiling of sex cord stromal tumors from<i>Men1</i>heterozygous mice identifies altered TGF-β signaling, decreased Gata6 and increased Csf1r expression" @default.
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- W2038861845 cites W1969565221 @default.
- W2038861845 cites W1983385874 @default.
- W2038861845 cites W1986523833 @default.
- W2038861845 cites W1987057361 @default.
- W2038861845 cites W1988222759 @default.
- W2038861845 cites W1992981977 @default.
- W2038861845 cites W1994057134 @default.
- W2038861845 cites W1996844977 @default.
- W2038861845 cites W2001581474 @default.
- W2038861845 cites W2004333640 @default.
- W2038861845 cites W2011170002 @default.
- W2038861845 cites W2013216633 @default.
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- W2038861845 cites W2017633360 @default.
- W2038861845 cites W2019181873 @default.
- W2038861845 cites W2030094937 @default.
- W2038861845 cites W2032869919 @default.
- W2038861845 cites W2035503420 @default.
- W2038861845 cites W2038539769 @default.
- W2038861845 cites W2039313820 @default.
- W2038861845 cites W2045647805 @default.
- W2038861845 cites W2047030157 @default.
- W2038861845 cites W2048469633 @default.
- W2038861845 cites W2055280081 @default.
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- W2038861845 cites W2066515353 @default.
- W2038861845 cites W2066989972 @default.
- W2038861845 cites W2069398063 @default.
- W2038861845 cites W2069414088 @default.
- W2038861845 cites W2074883939 @default.
- W2038861845 cites W2079649151 @default.
- W2038861845 cites W2082941836 @default.
- W2038861845 cites W2086152873 @default.
- W2038861845 cites W2094651478 @default.
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- W2038861845 cites W2132207544 @default.
- W2038861845 cites W2137691214 @default.
- W2038861845 cites W2142747205 @default.
- W2038861845 cites W2144948631 @default.
- W2038861845 cites W2150056778 @default.
- W2038861845 cites W2150111853 @default.
- W2038861845 cites W2150212366 @default.
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- W2038861845 cites W2153420148 @default.
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- W2038861845 cites W2157532493 @default.
- W2038861845 cites W2162263424 @default.
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- W2038861845 cites W2171539702 @default.
- W2038861845 cites W297450206 @default.
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- W2038861845 doi "https://doi.org/10.1002/ijc.24057" @default.
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