Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038861852> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2038861852 endingPage "227" @default.
- W2038861852 startingPage "221" @default.
- W2038861852 abstract "The O6-alkylation of guanine residues in DNA treated with alkylating agents induce mutations due to mis-pairing resulting from the deprotonation of N1. In addition to the deprotonation of N1, the conformation of the O6-alkyl group with respect to N7 of guanine is very important. Here, we present X-ray crystallographic evidence that shows that the methyl group in O6-methylguanosine has a preference for the distal conformation, blocking the Watson-Crick sites. This distal conformation persists in the solid state for several analogs of O6-alkylguanosine also. This preferred conformation agrees with the result that poly(O6-methyl GMP) does not form any stable complex with poly(U). However, the mispairing of O6-methylguanine with thymine and the resultant G----A transition is known from in vitro studies. The above two opposite results strongly indicate that the conformation of the O6-alkyl group and the base pairing properties of O6-alkylguanine at the monomer and polymer levels must be different from the situation when the modified base is embedded with a small frequency in a duplex. It is interesting to note that the sterical blocking of the Watson-Crick site at the monomer level and the altered base pairing properties when present as occasional bases in a duplex emerge as a common property for several mutagenic bases like O6-alkylguanines, O4-methyluracil and N4-hydroxycytosine." @default.
- W2038861852 created "2016-06-24" @default.
- W2038861852 creator A5027949125 @default.
- W2038861852 creator A5076895341 @default.
- W2038861852 date "1986-01-01" @default.
- W2038861852 modified "2023-09-23" @default.
- W2038861852 title "Conformation of O<sup>6</sup>-alkylguanosines: molecular mechanism of mutagenesis" @default.
- W2038861852 doi "https://doi.org/10.1093/carcin/7.2.221" @default.
- W2038861852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3948312" @default.
- W2038861852 hasPublicationYear "1986" @default.
- W2038861852 type Work @default.
- W2038861852 sameAs 2038861852 @default.
- W2038861852 citedByCount "25" @default.
- W2038861852 countsByYear W20388618522016 @default.
- W2038861852 countsByYear W20388618522018 @default.
- W2038861852 countsByYear W20388618522020 @default.
- W2038861852 countsByYear W20388618522021 @default.
- W2038861852 countsByYear W20388618522023 @default.
- W2038861852 crossrefType "journal-article" @default.
- W2038861852 hasAuthorship W2038861852A5027949125 @default.
- W2038861852 hasAuthorship W2038861852A5076895341 @default.
- W2038861852 hasConcept C104317684 @default.
- W2038861852 hasConcept C118629725 @default.
- W2038861852 hasConcept C143065580 @default.
- W2038861852 hasConcept C145148216 @default.
- W2038861852 hasConcept C161790260 @default.
- W2038861852 hasConcept C16318435 @default.
- W2038861852 hasConcept C164361826 @default.
- W2038861852 hasConcept C166940927 @default.
- W2038861852 hasConcept C178790620 @default.
- W2038861852 hasConcept C185581394 @default.
- W2038861852 hasConcept C185592680 @default.
- W2038861852 hasConcept C188027245 @default.
- W2038861852 hasConcept C2776023528 @default.
- W2038861852 hasConcept C2776858809 @default.
- W2038861852 hasConcept C2778301229 @default.
- W2038861852 hasConcept C2780263894 @default.
- W2038861852 hasConcept C2780642029 @default.
- W2038861852 hasConcept C512185932 @default.
- W2038861852 hasConcept C521977710 @default.
- W2038861852 hasConcept C552990157 @default.
- W2038861852 hasConcept C55493867 @default.
- W2038861852 hasConcept C61234307 @default.
- W2038861852 hasConcept C71240020 @default.
- W2038861852 hasConcept C8010536 @default.
- W2038861852 hasConcept C99611785 @default.
- W2038861852 hasConceptScore W2038861852C104317684 @default.
- W2038861852 hasConceptScore W2038861852C118629725 @default.
- W2038861852 hasConceptScore W2038861852C143065580 @default.
- W2038861852 hasConceptScore W2038861852C145148216 @default.
- W2038861852 hasConceptScore W2038861852C161790260 @default.
- W2038861852 hasConceptScore W2038861852C16318435 @default.
- W2038861852 hasConceptScore W2038861852C164361826 @default.
- W2038861852 hasConceptScore W2038861852C166940927 @default.
- W2038861852 hasConceptScore W2038861852C178790620 @default.
- W2038861852 hasConceptScore W2038861852C185581394 @default.
- W2038861852 hasConceptScore W2038861852C185592680 @default.
- W2038861852 hasConceptScore W2038861852C188027245 @default.
- W2038861852 hasConceptScore W2038861852C2776023528 @default.
- W2038861852 hasConceptScore W2038861852C2776858809 @default.
- W2038861852 hasConceptScore W2038861852C2778301229 @default.
- W2038861852 hasConceptScore W2038861852C2780263894 @default.
- W2038861852 hasConceptScore W2038861852C2780642029 @default.
- W2038861852 hasConceptScore W2038861852C512185932 @default.
- W2038861852 hasConceptScore W2038861852C521977710 @default.
- W2038861852 hasConceptScore W2038861852C552990157 @default.
- W2038861852 hasConceptScore W2038861852C55493867 @default.
- W2038861852 hasConceptScore W2038861852C61234307 @default.
- W2038861852 hasConceptScore W2038861852C71240020 @default.
- W2038861852 hasConceptScore W2038861852C8010536 @default.
- W2038861852 hasConceptScore W2038861852C99611785 @default.
- W2038861852 hasIssue "2" @default.
- W2038861852 hasLocation W20388618521 @default.
- W2038861852 hasLocation W20388618522 @default.
- W2038861852 hasOpenAccess W2038861852 @default.
- W2038861852 hasPrimaryLocation W20388618521 @default.
- W2038861852 hasRelatedWork W139804750 @default.
- W2038861852 hasRelatedWork W2003294639 @default.
- W2038861852 hasRelatedWork W2024044539 @default.
- W2038861852 hasRelatedWork W2031698103 @default.
- W2038861852 hasRelatedWork W2073897691 @default.
- W2038861852 hasRelatedWork W2090615979 @default.
- W2038861852 hasRelatedWork W2100458592 @default.
- W2038861852 hasRelatedWork W2182674531 @default.
- W2038861852 hasRelatedWork W2928949912 @default.
- W2038861852 hasRelatedWork W986273033 @default.
- W2038861852 hasVolume "7" @default.
- W2038861852 isParatext "false" @default.
- W2038861852 isRetracted "false" @default.
- W2038861852 magId "2038861852" @default.
- W2038861852 workType "article" @default.