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- W2038861887 abstract "We present OnTheFly (http://bhapp.c2b2.columbia.edu/OnTheFly/index.php), a database comprising a systematic collection of transcription factors (TFs) of Drosophila melanogaster and their DNA-binding sites. TFs predicted in the Drosophila melanogaster genome are annotated and classified and their structures, obtained via experiment or homology models, are provided. All known preferred TF DNA-binding sites obtained from the B1H, DNase I and SELEX methodologies are presented. DNA shape parameters predicted for these sites are obtained from a high throughput server or from crystal structures of protein-DNA complexes where available. An important feature of the database is that all DNA-binding domains and their binding sites are fully annotated in a eukaryote using structural criteria and evolutionary homology. OnTheFly thus provides a comprehensive view of TFs and their binding sites that will be a valuable resource for deciphering non-coding regulatory DNA." @default.
- W2038861887 created "2016-06-24" @default.
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- W2038861887 date "2013-11-22" @default.
- W2038861887 modified "2023-09-23" @default.
- W2038861887 title "OnTheFly: a database of<i>Drosophila melanogaster</i>transcription factors and their binding sites" @default.
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- W2038861887 doi "https://doi.org/10.1093/nar/gkt1165" @default.
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