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- W2038862301 abstract "ABSTRACT Porphyromonas gingivalis is a Gram-negative obligate anaerobe that has been implicated in the etiology of adult periodontitis. We recently introduced a Drosophila melanogaster killing model for examination of P. gingivalis -host interactions. In the current study, the Drosophila killing model was used to characterize the host response to P. gingivalis infection by identifying host components that play a role during infection. Drosophila immune response gene mutants were screened for altered susceptibility to killing by P. gingivalis . The Imd signaling pathway was shown to be important for the survival of Drosophila infected by nonencapsulated P. gingivalis strains but was dispensable for the survival of Drosophila infected by encapsulated P. gingivalis strains. The P. gingivalis capsule was shown to mediate resistance to killing by Drosophila antimicrobial peptides (Imd pathway-regulated cecropinA and drosocin) and human beta-defensin 3. Drosophila thiol-ester protein II (Tep II) and Tep IV and the tumor necrosis factor (TNF) homolog Eiger were also involved in the immune response against P. gingivalis infection, while the scavenger receptors Eater and Croquemort played no roles in the response to P. gingivalis infection. This study demonstrates that the Drosophila killing model is a useful high-throughput model for characterizing the host response to P. gingivalis infection and uncovering novel interactions between the bacterium and the host." @default.
- W2038862301 created "2016-06-24" @default.
- W2038862301 creator A5016083305 @default.
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- W2038862301 creator A5041240035 @default.
- W2038862301 creator A5058998067 @default.
- W2038862301 date "2011-01-01" @default.
- W2038862301 modified "2023-10-14" @default.
- W2038862301 title "<i>Porphyromonas gingivalis</i>-Host Interactions in a<i>Drosophila melanogaster</i>Model" @default.
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- W2038862301 cites W1574137340 @default.
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- W2038862301 cites W1870268639 @default.
- W2038862301 cites W1910488455 @default.
- W2038862301 cites W1938066666 @default.
- W2038862301 cites W1972350252 @default.
- W2038862301 cites W1973515352 @default.
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- W2038862301 cites W1995412010 @default.
- W2038862301 cites W1995879974 @default.
- W2038862301 cites W1996858055 @default.
- W2038862301 cites W1998741829 @default.
- W2038862301 cites W1999788026 @default.
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- W2038862301 cites W2023331434 @default.
- W2038862301 cites W2025937246 @default.
- W2038862301 cites W2025973083 @default.
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- W2038862301 cites W2030829246 @default.
- W2038862301 cites W2034349300 @default.
- W2038862301 cites W2039621386 @default.
- W2038862301 cites W2039819108 @default.
- W2038862301 cites W2041224982 @default.
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- W2038862301 cites W2052851334 @default.
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- W2038862301 cites W2054113968 @default.
- W2038862301 cites W2058926145 @default.
- W2038862301 cites W2059624134 @default.
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- W2038862301 cites W2075508889 @default.
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- W2038862301 cites W2124138257 @default.
- W2038862301 cites W2124381039 @default.
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- W2038862301 cites W2126880286 @default.
- W2038862301 cites W2133857336 @default.
- W2038862301 cites W2144671897 @default.
- W2038862301 cites W2147892714 @default.
- W2038862301 cites W2154701841 @default.
- W2038862301 cites W2157379357 @default.
- W2038862301 cites W2159334577 @default.
- W2038862301 cites W2159604301 @default.
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- W2038862301 doi "https://doi.org/10.1128/iai.00785-10" @default.
- W2038862301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3019892" @default.
- W2038862301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21041486" @default.
- W2038862301 hasPublicationYear "2011" @default.
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