FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038862395> ?p ?o ?g. }

• W2038862395 endingPage "e53133" @default.
• W2038862395 startingPage "e53133" @default.
• W2038862395 abstract "Background Left ventricular hypertrophy is enhanced by an inflammatory state and stimulation of various cytokines. Pentraxin 3 (PTX3) is rapidly produced in response to inflammatory signals, and high plasma PTX3 levels are seen in patients with heart failure. This study aimed to examine the influence of PTX3 on cardiac hypertrophy and left ventricular dysfunction with respect to pressure overload. Methods and Results PTX3 systemic knockout (PTX3-KO) mice, transgenic mice with cardiac-specific overexpression of PTX3 (PTX3-TG), and the respective wild-type (WT) littermate mice were subjected to transverse aortic constriction (TAC) or a sham operation. Cardiac PTX3 expression increased after TAC in WT mice. In vitro, hydrogen peroxide induced the expression of PTX3 in both cardiac myocytes and cardiac fibroblasts. Recombinant PTX3 phosphorylated extracellular signal–regulated kinase 1/2 (ERK1/2) in cardiac fibroblasts. Phosphorylation of cardiac ERK1/2 and nuclear factor kappa-B after TAC was attenuated in the PTX3-KO mice but was enhanced in the PTX3-TG mice compared with WT mice. Interleukin-6 and connective tissue growth factor production was lower in the PTX3-KO mice than in the WT mice, but this was augmented in the PTX3-TG mice than in the WT mice. Echocardiography revealed that adverse remodeling with left ventricular dysfunction, as well as with increased interstitial fibrosis, was enhanced in PTX3-TG mice, while these responses were suppressed in PTX3-KO mice. Conclusion The local inflammatory mediator PTX3 directly modulates the hypertrophic response and ventricular dysfunction following an increased afterload." @default.
• W2038862395 created "2016-06-24" @default.
• W2038862395 creator A5004466344 @default.
• W2038862395 creator A5015210533 @default.
• W2038862395 creator A5018539336 @default.
• W2038862395 creator A5020299465 @default.
• W2038862395 creator A5020798905 @default.
• W2038862395 creator A5022557754 @default.
• W2038862395 creator A5036596096 @default.
• W2038862395 creator A5044778439 @default.
• W2038862395 creator A5047342884 @default.
• W2038862395 creator A5051701709 @default.
• W2038862395 creator A5064704397 @default.
• W2038862395 creator A5069074637 @default.
• W2038862395 creator A5080120159 @default.
• W2038862395 creator A5085893721 @default.
• W2038862395 date "2013-01-23" @default.
• W2038862395 modified "2023-10-15" @default.
• W2038862395 title "Long Pentraxin PTX3 Exacerbates Pressure Overload–Induced Left Ventricular Dysfunction" @default.
• W2038862395 cites W107041847 @default.
• W2038862395 cites W1968202984 @default.
• W2038862395 cites W1979904436 @default.
• W2038862395 cites W1982338427 @default.
• W2038862395 cites W1993215640 @default.
• W2038862395 cites W2000536297 @default.
• W2038862395 cites W2023515446 @default.
• W2038862395 cites W2044748499 @default.
• W2038862395 cites W2046069591 @default.
• W2038862395 cites W2050751355 @default.
• W2038862395 cites W2059959576 @default.
• W2038862395 cites W2063121399 @default.
• W2038862395 cites W2064209431 @default.
• W2038862395 cites W2066397836 @default.
• W2038862395 cites W2066436387 @default.
• W2038862395 cites W2066885413 @default.
• W2038862395 cites W2081878872 @default.
• W2038862395 cites W2088888272 @default.
• W2038862395 cites W2088918935 @default.
• W2038862395 cites W2099884761 @default.
• W2038862395 cites W2100697065 @default.
• W2038862395 cites W2101490763 @default.
• W2038862395 cites W2105654067 @default.
• W2038862395 cites W2105993413 @default.
• W2038862395 cites W2109450293 @default.
• W2038862395 cites W2117953915 @default.
• W2038862395 cites W2119293574 @default.
• W2038862395 cites W2135648252 @default.
• W2038862395 cites W2142554660 @default.
• W2038862395 cites W2144648204 @default.
• W2038862395 cites W2149576103 @default.
• W2038862395 cites W2151489897 @default.
• W2038862395 cites W2156565014 @default.
• W2038862395 cites W2160125610 @default.
• W2038862395 cites W2164540928 @default.
• W2038862395 cites W2165414471 @default.
• W2038862395 cites W2166781237 @default.
• W2038862395 cites W2407716352 @default.
• W2038862395 doi "https://doi.org/10.1371/journal.pone.0053133" @default.
• W2038862395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3553104" @default.
• W2038862395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23372656" @default.
• W2038862395 hasPublicationYear "2013" @default.
• W2038862395 type Work @default.
• W2038862395 sameAs 2038862395 @default.
• W2038862395 citedByCount "28" @default.
• W2038862395 countsByYear W20388623952013 @default.
• W2038862395 countsByYear W20388623952014 @default.
• W2038862395 countsByYear W20388623952015 @default.
• W2038862395 countsByYear W20388623952016 @default.
• W2038862395 countsByYear W20388623952017 @default.
• W2038862395 countsByYear W20388623952018 @default.
• W2038862395 countsByYear W20388623952019 @default.
• W2038862395 countsByYear W20388623952020 @default.
• W2038862395 countsByYear W20388623952021 @default.
• W2038862395 countsByYear W20388623952022 @default.
• W2038862395 crossrefType "journal-article" @default.
• W2038862395 hasAuthorship W2038862395A5004466344 @default.
• W2038862395 hasAuthorship W2038862395A5015210533 @default.
• W2038862395 hasAuthorship W2038862395A5018539336 @default.
• W2038862395 hasAuthorship W2038862395A5020299465 @default.
• W2038862395 hasAuthorship W2038862395A5020798905 @default.
• W2038862395 hasAuthorship W2038862395A5022557754 @default.
• W2038862395 hasAuthorship W2038862395A5036596096 @default.
• W2038862395 hasAuthorship W2038862395A5044778439 @default.
• W2038862395 hasAuthorship W2038862395A5047342884 @default.
• W2038862395 hasAuthorship W2038862395A5051701709 @default.
• W2038862395 hasAuthorship W2038862395A5064704397 @default.
• W2038862395 hasAuthorship W2038862395A5069074637 @default.
• W2038862395 hasAuthorship W2038862395A5080120159 @default.
• W2038862395 hasAuthorship W2038862395A5085893721 @default.
• W2038862395 hasBestOaLocation W20388623951 @default.
• W2038862395 hasConcept C126322002 @default.
• W2038862395 hasConcept C127901578 @default.
• W2038862395 hasConcept C134018914 @default.
• W2038862395 hasConcept C167414201 @default.
• W2038862395 hasConcept C2776914184 @default.
• W2038862395 hasConcept C2778198053 @default.
• W2038862395 hasConcept C2778271984 @default.
• W2038862395 hasConcept C2779537366 @default.

• next