Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038863889> ?p ?o ?g. }
- W2038863889 endingPage "311" @default.
- W2038863889 startingPage "303" @default.
- W2038863889 abstract "Currently available therapies for diabetes or obesity produce modest efficacy and are usually used in combination with agents targeting cardiovascular risk factors. Fibroblast growth factor 21 (FGF21) is a circulating protein with pleiotropic metabolic actions; pharmacological doses of FGF21 produce anti-diabetic, lipid-lowering, and weight-reducing effects in rodents. Several potential benefits have translated to non-human primates and obese humans with type 2 diabetes (T2D). Accumulating results point to a specific receptor complex and actions in adipose tissue, liver, and brain; several pathways lead to enhanced fatty acid oxidation, increased insulin sensitivity, and augmented energy expenditure. A range of strategies are being explored to derive potent, safe, and convenient therapies which could potentially represent novel approaches to prevent and treat a variety of metabolic disorders." @default.
- W2038863889 created "2016-06-24" @default.
- W2038863889 creator A5064772594 @default.
- W2038863889 creator A5082280074 @default.
- W2038863889 date "2014-06-01" @default.
- W2038863889 modified "2023-10-09" @default.
- W2038863889 title "FGF21-based pharmacotherapy – potential utility for metabolic disorders" @default.
- W2038863889 cites W1486302655 @default.
- W2038863889 cites W1523543948 @default.
- W2038863889 cites W1560066047 @default.
- W2038863889 cites W1943524962 @default.
- W2038863889 cites W1963690531 @default.
- W2038863889 cites W1966181749 @default.
- W2038863889 cites W1972717747 @default.
- W2038863889 cites W1977516373 @default.
- W2038863889 cites W1978039711 @default.
- W2038863889 cites W1983397453 @default.
- W2038863889 cites W1991380553 @default.
- W2038863889 cites W1993235686 @default.
- W2038863889 cites W1993551202 @default.
- W2038863889 cites W2000368348 @default.
- W2038863889 cites W2000665430 @default.
- W2038863889 cites W2003495422 @default.
- W2038863889 cites W2005063766 @default.
- W2038863889 cites W2007979003 @default.
- W2038863889 cites W2015339950 @default.
- W2038863889 cites W2020958481 @default.
- W2038863889 cites W2025139842 @default.
- W2038863889 cites W2028617804 @default.
- W2038863889 cites W2029880965 @default.
- W2038863889 cites W2032668499 @default.
- W2038863889 cites W2032787352 @default.
- W2038863889 cites W2037001212 @default.
- W2038863889 cites W2040319473 @default.
- W2038863889 cites W2042911346 @default.
- W2038863889 cites W2043531340 @default.
- W2038863889 cites W2044760021 @default.
- W2038863889 cites W2048285167 @default.
- W2038863889 cites W2048411348 @default.
- W2038863889 cites W2050259739 @default.
- W2038863889 cites W2051977733 @default.
- W2038863889 cites W2054119106 @default.
- W2038863889 cites W2056940322 @default.
- W2038863889 cites W2060734703 @default.
- W2038863889 cites W2061333499 @default.
- W2038863889 cites W2062842771 @default.
- W2038863889 cites W2064125892 @default.
- W2038863889 cites W2073654379 @default.
- W2038863889 cites W2076037986 @default.
- W2038863889 cites W2079132151 @default.
- W2038863889 cites W2082930819 @default.
- W2038863889 cites W2086624706 @default.
- W2038863889 cites W2093551202 @default.
- W2038863889 cites W2095480970 @default.
- W2038863889 cites W2100232436 @default.
- W2038863889 cites W2109071746 @default.
- W2038863889 cites W2111653877 @default.
- W2038863889 cites W2114650931 @default.
- W2038863889 cites W2114836473 @default.
- W2038863889 cites W2119331212 @default.
- W2038863889 cites W2119351413 @default.
- W2038863889 cites W2121049950 @default.
- W2038863889 cites W2123472956 @default.
- W2038863889 cites W2126188293 @default.
- W2038863889 cites W2127359651 @default.
- W2038863889 cites W2129100766 @default.
- W2038863889 cites W2129631252 @default.
- W2038863889 cites W2130700195 @default.
- W2038863889 cites W2131192628 @default.
- W2038863889 cites W2131622156 @default.
- W2038863889 cites W2133997161 @default.
- W2038863889 cites W2134810803 @default.
- W2038863889 cites W2134944069 @default.
- W2038863889 cites W2136396947 @default.
- W2038863889 cites W2136477171 @default.
- W2038863889 cites W2140313261 @default.
- W2038863889 cites W2144461742 @default.
- W2038863889 cites W2145044799 @default.
- W2038863889 cites W2145142659 @default.
- W2038863889 cites W2151175711 @default.
- W2038863889 cites W2155010729 @default.
- W2038863889 cites W2163644328 @default.
- W2038863889 cites W2165852917 @default.
- W2038863889 cites W2165961239 @default.
- W2038863889 cites W2168118376 @default.
- W2038863889 cites W2334946637 @default.
- W2038863889 cites W2063897622 @default.
- W2038863889 doi "https://doi.org/10.1016/j.tem.2014.03.001" @default.
- W2038863889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24709036" @default.
- W2038863889 hasPublicationYear "2014" @default.
- W2038863889 type Work @default.
- W2038863889 sameAs 2038863889 @default.
- W2038863889 citedByCount "141" @default.
- W2038863889 countsByYear W20388638892014 @default.
- W2038863889 countsByYear W20388638892015 @default.
- W2038863889 countsByYear W20388638892016 @default.
- W2038863889 countsByYear W20388638892017 @default.
- W2038863889 countsByYear W20388638892018 @default.